孫中生博士，研究員，中國科學院大學魏橋講席教授。1982年北京大學學士；1992年美國德克薩斯A&M大學博士。曾任路易斯安那州立大學神經學中心和康奈爾大學威爾醫學院助理教授。曾首次克隆了哺乳動物關鍵的生物鍾基因-mPer1和mPer2，揭示了哺乳動物生物鍾的分子生物學基礎，1997年榮獲Science雜誌十大科學突破。2017年曾獲第七屆中國科學院北京分院科技成果轉化三等獎，2018年“藥明康德生命化學研究獎”學者獎，國務院政府特殊津貼專家。主要通過開發基因組、轉錄組、表觀基因組的新技術及分析工具來理解生命現象與人類疾病。開發了多個囊括臨床數據與遺傳信息於一體的強大分析工具和數據庫，為包括孤獨症在內的複雜疾病的候選基因的篩選提供了方法學支撐。利用自主開發的工具係統地研究了自閉症等神經精神疾病的候選基因、臨床亞型以及基因型與臨床表型之間的相互關係，相關研究為複雜疾病的精準診療數據支撐。整合分析了不同神經精神疾病共有和特有的新發突變和候選基因，為臨床上準確診療自閉症以及亞型分類提供了科學的遺傳學依據；研究了頭圍大小相關基因在自閉症中的遺傳機製研究；並在國際上首次從遺傳學角度解讀自閉症臨床診斷指南DSM-5。還基於大樣本量的中國神經發育障礙患者的靶向測序進一步完善了中國患者的遺傳圖譜，並進一步整合公共數據鑒定出新的後選基因以及中國患者特有的遺傳特征及風險基因。在Cell、Molecular Psychiatry、American Journal of Human Genetics、Blood、Advanced science、Nucleic Acids Research、Cell Reports等著名國際期刊上發表論文130餘篇。

致力於開發基因組、轉錄組、表觀基因組的新技術及分析工具，並利用這些技術和分析工具來研究癌症、高級情緒和複雜行為的遺傳和表觀遺傳調控機製。

1. Wang Y,Zhang K,Guo J,Yang S,Shi X,Pan J,Sun Z,Zou J,Li Y,Li Y,Fan T,Wei S,Cheng F,Zeng C,Li J,Zhang T*,Sun Z*. Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. Advanced Science. 2023,10,2204018.
2. Li Y,FanT,Li X,Liu L,Mao F,LiY,Miao Z,Zeng C,Song W,Pan J,Zhou S,Sunday ME,Wang H,Wang Y,* and Sun Z*. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors. Cell Reports. 2022,40(9):111289.
3. Wang T,Zhao T ,Liu L,Teng H,Fan T,Li Y,Wang Y,Li J*,Xia K*,and Sun Z*. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. eBioMedicine. 2022,81:104091.
4. Liang J,Zhang K,Yang J,Li X,Li Q,Wang Y,Cai W,Teng H* and Sun Z*. A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing. Briefings in Bioinformatics. 2021;5;22(6):bbab201.
5. Teng H,Xue M,Liang J,Wang X,Wang L,Wei W,Li C,Zhang Z,Li Q,Ran X,Shi X,Cai W,Wang W,Gao H,Sun Z*. Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma. Theranostics. 2020;10(7):3035-3048.
6. Teng H,Wei W,Li Q,Xue M,Shi X,Li X,Mao F*,Sun Z*. Prevalence and architecture of posttranscriptionally impaired synonymous mutations in 8320 genomes across 22 cancer types. Nucleic Acids Research.2020;48(3):1192-1205.
7. Li J,Hu S,Zhang K,Shi L,Zhang Y,Zhao T,Wang L,He X,Xia K,Liu C,Sun Z*. A comparative study of the genetic components of three subcategories of autism spectrum disorder. Mol Psychiatry. 2019;24(11):1720-1731.
8. Wang Y,Zeng C,Li J,Zhou Z,Ju X,Xia S,Li Y,Liu A,Teng H,Zhang K,Shi L,Bi C,Xie W,He X,Jia Z,Jiang Y,Cai T,Wu J,Xia K*,Sun Z*. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. Cell Rep. 2018;24(8):2029-2041.
9. Liu Y,Liang Y,Cicek AE,Li Z,Li J,Muhle RA,Krenzer M,Mei Y,Wang Y,Knoblauch N,Morrison J,Zhao S,Jiang Y,Geller E,Ionita-Laza I,Wu J Xia K,Noonan JP,Sun ZS*,He X*. A Statistical Framework for Mapping Risk Genes from De Novo Mutations in Whole-Genome-Sequencing Studies. American Journal of Human Genetics, 2018,102(6):1031-1047.
10. Liang J^#,Feng D^#,Cai W^#,Teng H,Mao F,Jiang Y,Hu S,Li X,Zhang Y,Liu B*,Sun Z*. Genetic landscape of papillary thyroid carcinoma in the Chinese population. The Journal of Pathology,2018,244(2):215-226.