趙方慶，研究員，博士生導師。先後獲得基金委優青（2017）、北京傑青（2018）、國家傑青（2020）和中國科學院特聘研究員（2022）。現任副主任、技術平台主任、中國生物信息學會基因組信息學分會主任。在Briefings in Bioinformatics、Science Bulletin、Science China Life Sciences、Genomics,Proteomics & Bioinformatics等國際學術刊物擔任副主編或編委。主要致力於建立高效的算法模型和實驗技術，探索人體微生物與非編碼RNA的結構組成與變化規律，以期解析它們與人類健康和疾病的關係。在Cell、Gut、Nature Biotechnology、Nature Methods、Nature Computational Science和Nature Communications等刊物上發表通訊作者論文100餘篇；論文總引用次數超過1.5萬次，其中十餘篇入選ESI高被引論文；連續6年榮獲“中國科學院優秀導師獎”（2017～2023），3次獲得“中國科學院大學領雁獎章”、“中國科學院優秀共產黨員”、“中國科學院李佩優秀教師獎”、“中國科學院朱李月華優秀教師獎”、“中國科學院大學必和必拓導師獎”；培養的研究生已有7人次獲得“中國科學院院長獎”（含3次特別獎）和“中國科學院優博論文”。現承擔國家重點研發計劃首席科學家、基金委傑青和重點項目。

1. 腸道菌群與健康

整合基因組學、計算生物學和係統生物學手段，研究腸道菌群的結構組成與變化規律，以及微生物與宿主的相互作用等問題。

2. 環形非編碼RNA

建立環形RNA識別、定量、轉錄本組裝、可變剪接識別和功能注釋等統計學模型和算法，為解析其形成機製和功能提供方法學工具。

3. 單細胞及空間多組學技術

基於微流控及深度學習技術，建立空間轉錄/蛋白/代謝組學新方法，揭示細胞及功能的空間異質性，深入理解腸道菌群及其代謝產物對宿主的影響。

近5年代表性成果：

1. He R,Zhu J,Ji P* & Zhao F*. SEVtras delineates small extracellular vesicles at droplet resolution from single-cell transcriptomes. Nature Methods,2024,21:259-266.
2. Zhou T,Xiao L,Zuo Z* & Zhao F*. MAMI: a comprehensive database of mother-infant microbiome and probiotic resources. Nucleic Acids Research,2024,52:D738-D746.
3. Li Z,Zhang B,Wang N,Zuo Z,Wei H & Zhao F*. A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota. Gut,2023,72:686-698.
4. Hou L,Zhang J* & Zhao F*. Full-length circular RNA profiling by nanopore sequencing and CIRI-long. Nature Protocols,2023,18:1795-1813.
5. Xiao L & Zhao F*. ­­Microbial transmission,colonization and succession: from pregnancy to infancy. Gut,2023,72: 772-786.
6. He R,Li P,Wang J,Cui B,Zhang F & Zhao F*. The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation. Gut Microbes,2022,14(1):e2100197.
7. Xiao L,Zhang F & Zhao F*. Large-scale microbiome data integration enables robust biomarker identification. Nature Computational Science,2022,2: 307-316.
8. Wu W,Zhang J,Cao X,Cai Z & Zhao F*. Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing. Nature Communications,2022,13(1):3242.
9. Yang J,Hou L,Wang J,Xiao L,Zhang J,Yin N,Yao S,Cheng K,Zhang W,Shi Z,Wang J,Jiang H,Huang N,You Y,Lin M,Shang R,Wei Y*,Zhao Y* & Zhao F*. Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins. Gut,2022,71:2451-2462.
10. Chen S,Cao X,Zhang J,Wu W,Zhang B & Zhao F*. circVAMP3 drivesCAPRIN1phase separation and inhibits hepatocellular carcinoma by suppressing c-Myc translation. Advanced Science,2022,9(8):e2103817.
11. Yu Y,Zhang B,Ji P,Zuo Z,Huang Y,Wang N,Liu C,Liu SJ & Zhao F*. Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8^+/- mouse model of ASD-like behavior. Nature Communications,2022,13(1):1151.
12. Zhang J,Hou L,Zuo Z,Zhang X,Xue Y & Zhao F*. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. Nature Biotechnology,2021,39:836-845.
13. Xiao L,Wang J,Zheng J,Li X & Zhao F*. Deterministic transition of enterotypes shapes the infant gut microbiome at an early age. Genome Biology,2021,22:243.
14. Wang J,Li Z,Ma X,Du L,Jia Z,Cui X,Yu L,Xiao L,Zhang B,Fan H & Zhao F*. Translocation of vaginal microbiota is involved in impairment and protection of uterine health. Nature Communications,2021,12:4191.
15. Jia N, Wang J,Shi W, Du L,Sun Y,et al.,Tick Genome and Microbiome Consortium, Zhao F* & Cao WC*. Large-scale comparative analyses of tick genomes elucidate their genetic diversity and vector capacities. Cell,2020,182(5):1328-1340
16. Zhang J, Chen S, Yang J & Zhao F*. Accurate quantification of circular RNAs identifies extensive circular isoform switching events. Nature Communications,2020,11:90.
17. Wu W,Ji P & Zhao F*. CircAltas: An integrated resource of one million highly confident circular RNAs from 1,070 transcriptomes of vertebrates. Genome Biology,2020,21:101.
18. Wang J, Jia Z, Zhang B,Peng L & Zhao F*. Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract. Gut,2020,69:1355-1356.
19. Ji P, Wu W, Chen S, et al, Zhao F*. Expanded expression landscape and prioritization of circular RNAs in mammals. Cell Reports, 2019,26 (12),3444-3460.
20. Wang J,Zheng J, Shi W, Du N,Xu X, Zhang Y, Ji P, Zhang F, Jia Z,Wang Y,Zheng Z,Zhang H & Zhao F*. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. Gut,2018, 67:1614-1625.

招生視頻：https://mp.weixin.qq.com/s/vxgFlYQA3UqdzJyfw3wb6g