韓玉嶺，博士，必威精装版app西汉姆联 幹細胞與生殖生物學國家重點實驗室研究員，博士生導師。2013年於南開大學生命科學學院獲學士學位，2019年獲中國科學院生物物理研究所博士學位。同年赴康奈爾大學威爾醫學院從事博士後研究。2024年1月全職加入必威精装版app西汉姆联 ，研究方向是病毒與宿主相互作用的分子機理。通過以胚胎幹細胞和誘導多能幹細胞分化的多種組織細胞/類器官為模型，研究病毒感染，並篩選潛在的抗病毒藥物。以第一作者或共同一作發表論文10篇，代表論著包括Nature (2021) ，Cell (2019) ，Nature Methods (2022) ，Cell Stem Cell (2020, 2022, 2024) ， Circulation Research (2021, 2022) 等，總引用1600餘次。

病毒感染嚴重威脅人類健康。利用人類胚胎幹細胞和多能幹細胞分化不同組織細胞/類器官研究病毒感染，可以克服傳統細胞係對複雜的人體細胞和器官係統建模的局限。本課題組利用幹細胞分化的類器官來研究傳染性疾病，結合多組學測序技術和高通量藥物篩選平台，深入研究病毒與宿主相互作用的機製，探索潛在的治療策略。

1. Han Y^#, Duan X^#, Yang L^#, Nilsson-Payant BE^#, Wang P^#, Duan F^#, Tang X^#, Yaron TM^#, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen DT, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H^#, Cantley LC^*, tenOever BR^*, Ho DD^*, Pan FC^*, Evans T^*, Chen HJ^*, Schwartz RE^* and Chen S^*. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021; 589: 270-275
2. Wang X^#, Xuan Y^#, Han Y^#, Ding X, Ye K, Yang F, Gao P, Goff SP and Gao G^*. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Cell. 2019; 176:625-635 e14.
3. Han Y^#, Tan L^#, Zhou T^#, Yang L^#, Carrau L^#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T and Chen S^*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022; 29:1475-1490 e6.
4. Yang L^#, Han Y^#, Nilsson-Payant BE^#, Gupta V^#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffre F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC^*, Ho DD^*, tenOever BR^*, Evans T^*, Schwartz RE^* and Chen S^*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020; 27:125-136 e7. Best of Cell Stem Cell 2020.
5. Han Y^#, Zhu J^#, Yang L^#, Nilsson-Payant BE^#, Hurtado R, Lacko L, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Zhengming Chen, Ho DD, Pitt GS, Schwartz RE^*, tenOever BR^*, Evans T^* and Chen S^*. SARS-CoV-2 infection Induces Ferroptosis of Sinoatrial Node-like Pacemaker Cells. Circ Res. 2022 130:963-977. Circulation Research Best Manuscript 2022.
6. Han Y^#, Yang L^#, Lacko L and Chen S^*. Human Organoid Models to Study SARS-CoV-2 Infection. Perspective, Nature Methods. 2022 4:418-428.
7. Yang L^#, Han Y^#, Jaffre F^#, Nilsson-Payant BE^#, Bram Y^#, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Chen Z, Xiang J, Ho DD, tenOever BR^*, Schwartz RE^*, Evans T^* and Chen S^*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 129:33-46. Cover story
8. Yang L^#, Kim TW^#, Han Y^#, Nair MS^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo SY, Lacko LA, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, van der Valk P, Titulaer MJ, Spoor JKH, Furler O'Brien RL, Bugiani M, W DJVdB, Schwartz RE^*, Ho DD^*, Studer L^* and Chen S^*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024.
9. Yang L^#, Nilsson-Payant BE^#, Han Y^#, Jaffré F^#, Zhu J^#, Wang P, Zhang T, Redmond D, Houghton S and Møller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD^*, Schwartz RE^*, tenOever BR, Evans T^* and Chen S^*. Cardiomyocytes Recruit Monocytes upon SARS-CoV-2 Infection by Secreting CCL2. Stem Cell Reports. 2021 Jul 20.
10. Yang L^#, Han Y^#, Zhou T^#, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, Giani AM, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T and Chen S^*. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023;26:107001.

2024年招生視頻：https://mp.weixin.qq.com/s/rU_TE7n6Cbi0UsFKVxl_Wg