姓  名: 劉佩佩
學  科: 再生醫學
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電子郵件: liupeipei@ioz.ac.cn
通訊地址: 北京市朝陽區北辰西路1號院5號 必威精装版app西汉姆联
必威精装版app西汉姆联 器官再生與智造全國重點實驗室 100101
更多信息: 幹細胞與神經發育疾病研究組     

簡曆介紹:

教育經曆:

(1) 2015-09 至 2018-07,必威精装版app西汉姆联 ,發育生物學,博士

(2) 2011-09 至 2014-07,廈門大學,細胞生物學,碩士

(3) 2007-09 至 2011-07,山東師範大學,生物科學,學士

科研與學術工作經曆:

(1) 2018-07 至 2024-12,必威精装版app西汉姆联 ,幹細胞與生殖生物學國家重點實驗室,助理研究員

(2) 2025-01 至 今,必威精装版app西汉姆联 ,幹細胞與生殖生物學國家重點實驗室,副研究員

研究領域:

以小鼠、人多能幹細胞及病人來源的組織或細胞為模型,從事神經發育、神經疾病機製與藥物靶點探索的研究,發現新型的相關疾病分子靶標及幹預治療策略

社會任職:

獲獎及榮譽:

承擔科研項目情況:

  • 國家自然科學青年基金項目(31900690),主持,2020-2022
  • 國家重點研發計劃項目(2021YFA1101400),科研骨幹,2021-2025
  • 中國科學院青促會,主持,2023- 2027

代表論著:

(#共同第一作者)

  1. Liu, P.P.,# Han, X#., Li, X.#, Dai, S.K., Xu, Y.J., Jiao, L.F., Du, H.Z., Zhao, L.H., Li, R.F., Teng, Z.Q., et al. (2025). An EED/PRC2-H19 Loop Regulates Cerebellar Development. Adv Sci (Weinh) 12, e2403591.
  2. Liu, P.P.#, Lu, S.P.#, Li, X.#, Tang, G.B., Liu, X., Dai, S.K., Jiao, L.F., Lin, X.W., Li, X.G., Hu, B., et al. (2023). Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus. Cell Death Differ 30, 2187-2199. 10.1038/s41418-023-01199-w.
  3. Liu, P.P.#, Dai, S.K.#, Mi, T.W.#, Tang, G.B., Wang, Z., Wang, H., Du, H.Z., Tang, Y., Teng, Z.Q., and Liu, C.M. (2022). Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med 14, e15795. 10.15252/emmm.202215795.
  4. Liu, X., Dai, S.K., Liu, P.P., and Liu, C.M. (2021). Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development. Cell Prolif 54, e13124. 10.1111/cpr.13124.
  5. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ*, Liu CM*. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Reports 2021, 22 (10): e52023.
  6. Liu PP#, Xu YJ#, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131. doi: 10.1016/j.stemcr.2019.05.010.
  7. Liu C, Dai SK, Sun Z, Wang Z, Liu PP, Du HZ, Yu S*, Liu CM*, Teng ZQ*. GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019 Jul 15;39:101501. doi: 10.1016/j.scr.2019.101501.
  8. Xu YJ#, Liu PP#, Ng SC, Teng ZQ, Liu CM*. Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol. 2019 Jul 10. pii: mjz058. doi: 10.1093/jmcb/mjz058.)
  9. Duan RS, Liu PP, Xi F, Wang WH, Tang GB, Wang RY*, Saijilafu*, Liu CM*. Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons. Biochem Biophys Res Commun. 2018 May 5;499(2):246-252
  10. Duan RS, Tang GB, Du HZ, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM*. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death Differ. 2018 Sep;25(9):1598-1611.
  11. Liu PP#, Xu YJ#, Teng ZQ, Liu CM*. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220.
  12. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ*, Liu CM*. MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells. Stem Cell Reports. 2017 Jul 11;9(1):190-202.
  13. Tang GB#, Zeng YQ#, Liu PP#, Mi TW, Zhang SF, Dai SK, Tang QY, Yang L, Xu YJ, Yan HL, Du HZ, Teng ZQ*, Zhou FQ*, Liu CM*. The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice. Front Mol Neurosci. 2017 Aug 24;10:267. 

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