姓  名: 王 明
學  科: 表觀遺傳調控機製與編輯技術/植物保護學
電話/傳真: +86-10-64807230 / 
電子郵件: wangming@ioz.ac.cn
通訊地址: 北京市朝陽區北辰西路1號院5號
必威精装版app西汉姆联 農業蟲害鼠害綜合治理研究國家重點實驗室 D513 100101
更多信息: 表觀遺傳工程研究組     

簡曆介紹:

王明,研究員,博士生導師,必威精装版app西汉姆联 表觀遺傳工程研究組組長。 2010年於中國農業大學生物學院獲得學士學位,2015年於美國加州大學河濱分校獲得博士學位,2015-2023年分別在美國加州大學河濱分校和加州大學洛杉磯分校進行博士後研究。2023年6月起加入必威精装版app西汉姆联 ,擔任表觀遺傳工程研究組組長,主要從事植物、昆蟲、病原三者互作過程中的表觀遺傳信號的傳遞與調控機製的研究,以及表觀基因組編輯工具的開發。代表性研究成果包括首次揭示了小RNA跨界調控植物與病菌互作,並開發了多個表觀基因組編輯工具調控植物基因表達。以第一或通訊作者(含共同)身份在ScienceNature Plants (3篇) ,Nature Communications (3篇) ,Trends in MicrobiologyCurrent Opinion in Plant Biology(2篇)等雜誌發表,總引用超過4300次,並取得2項美國專利。主持國家自然科學基金麵上項目和動物所自主部署建製化攻關項目,並參與農業生物育種重大項目等,為Nature Plants, New Phytologist等雜誌擔任審稿人。

研究領域:

媒介昆蟲傳播的植物病毒病害對我國農業生產構成了嚴重威脅,然而,目前對於植物的防禦機製、昆蟲的傳播途徑及病毒的致病機理的認識仍相對有限。本研究組專注於探索表觀遺傳信號在植物、昆蟲和病原間的傳遞與調控機製,結合表觀遺傳學、基因組學、分子生物學和合成生物學等方法,挖掘植物抗病基因並解析分子機理。同時,研究組也致力於開發和優化表觀基因組編輯工具,將其用於調控植物抗病基因的表達,創製農作物抗病種質。

1. 表觀遺傳信號調控植物、昆蟲與病原互作

通過高通量測序技術,解析植物的轉錄組、翻譯組、和表觀組等在植物與病蟲害互作前後所發生的變化,挖掘植物潛在的抗病基因,並使用分子生物學與遺傳學等方法進行驗證。

2. 開發表觀基因組編輯工具調控基因表達

以CRISPR/dCas和Zinc finger等係統為基因靶標係統結合不同的表觀遺傳相關蛋白,開發高效且精準的表觀基因組編輯工具,通過改造目標位點的表觀遺傳修飾,調控基因表達。並將該工具運用於植物抗病基因的調控,創製抗病種質。

社會任職:

獲獎及榮譽:

承擔科研項目情況:

代表論著:

(* 共同第一作者,#通訊作者):

  1. SE Jacobsen, M Wang. TOOLS FOR GENE SILENCING, US Patent App. 18/715,424, 2025
  2. Cheng Y*, Zhou Y*, Wang M#. Targeted gene regulation through epigenome editing in plants. Current Opinion in Plant Biology. 2024 Aug 1;80:102552.
  3. Wang M*, He Y*, Zhong Z, Papikian A, Wang S, Gardiner J, Ghoshal B, Feng S, Jami-Alahmadi Y, Wohlschlegel JA, Jacobsen SE. Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis. Nature Plants. 2025 Feb 11:1-2.
  4. Wang M*, Zhong Z*, Gallego-Bartolomé J, Li Z, Feng S, Kuo HY, Kan RL, Lam H, Richey JC, Tang L, Zhou J. A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis. Nature plants. 2023 Mar;9(3):460-72.
  5. Wang M*, Zhong Z*, Gallego-Bartolomé J, Feng S, Shih YH, Liu M, Zhou J, Richey JC, Ng C, Jami-Alahmadi Y, Wohlschlegel J. Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14. Nature Communications. 2023 Mar 28;14(1):1736.
  6. Wang M, Weiberg A, Lin FM, Thomma BP, Huang HD, Jin H. Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. Nature plants. 2016 Sep 19;2(10):1-0.
  7. Weiberg A*, Wang M*, Lin FM, Zhao H, Zhang Z, Kaloshian I, Huang HD, Jin H. Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science. 2013 Oct 4;342(6154):118-23.
  8. Li Z*, Wang M*, Zhong Z*, Gallego-Bartolomé J, Feng S, Jami-Alahmadi Y, Wang X, Wohlschlegel J, Bischof S, Long JA, Jacobsen SE. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. Nature Communications. 2023 Jul 12;14(1):4135.
  9. Zhong Z*, Wang Y*, Wang M*, Yang F, Thomas QA, Xue Y, Zhang Y, Liu W, Jami-Alahmadi Y, Xu L, Feng S. Histone chaperone ASF1 mediates H3. 3-H4 deposition in Arabidopsis. Nature communications. 2022 Nov 15;13(1):6970.
  10. Wang M, Jin H. Spray-induced gene silencing: a powerful innovative strategy for crop protection. Trends in microbiology. 2017 Jan 1;25(1):4-6.
  11. Wang M, Thomas N, Jin H. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre-and post-harvest plant protection. Current opinion in plant biology. 2017 Aug 1;38:133-41.
  12. Wang M*, Weiberg A*, DellotaE, Yamane D, Jin H. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA biology. 2017 Apr 3;14(4):421-8.
  13. Wang M*, Weiberg A*, Jin H. Pathogen small RNAs: a new class of effectors for pathogen attacks. Molecular Plant Pathology. 2015 Mar 12;16(3):219.
  14. Gardiner J*, Ghoshal B*, Wang M*, Jacobsen SE. CRISPR–Cas-mediated transcriptional control and epi-mutagenesis. Plant physiology. 2022 Apr 1;188(4):1811-24.
  15. Cai Q, Qiao L, Wang M, He B, Lin FM, Palmquist J, Huang SD, Jin H. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science. 2018 Jun 8;360(6393):1126-9.
  16. Wang S, Wang M, Ichino L, Boone BA, Zhong Z, Papareddy RK, Lin EK, Yun J, Feng S, Jacobsen SE. MBD2 couples DNA methylation to transposable element silencing during male gametogenesis. Nature Plants. 2024 Jan;10(1):13-24.
  17. Zhong Z, Xue Y, Harris CJ, Wang M, Li Z, Ke Y, Liu M, Zhou J, Jami-Alahmadi Y, Feng S, Wohlschlegel JA. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. Genome Biology. 2023 Apr 26;24(1):96.
  18. Liu W, Gallego-Bartolomé J, Zhou Y, Zhong Z, Wang M, Wongpalee SP, Gardiner J, Feng S, Kuo PH, Jacobsen SE. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. Nature communications. 2021 May 25;12(1):3130.
  19. Xue Y, Zhong Z, Harris CJ, Gallego-Bartolomé J, Wang M, Picard C, Cao X, Hua S, Kwok I, Feng S, Jami-Alahmadi Y. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature communications. 2021 Jul 13;12(1):4292.
  20. Weiberg A, Wang M, Bellinger M, Jin H. Small RNAs: a new paradigm in plant-microbe interactions. Annual Review of Phytopathology. 2014 Aug 4;52(1):495-516.
  21. Feng S, Zhong Z, Wang M, Jacobsen SE. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. Epigenetics & chromatin. 2020 Dec;13:1-7.
  22. Dong OX, Meteignier LV, Plourde MB, Ahmed B, Wang M, Jensen C, Jin H, Moffett P, Li X, Germain H. Arabidopsis TAF15b localizes to RNA processing bodies and contributes to snc1-mediated autoimmunity. Molecular Plant-Microbe Interactions. 2016 Apr 6;29(4):247-57.
  23. Hamby R, Wang M, Qiao L, Jin H. Synthesizing fluorescently labeled dsRNAs and sRNAs to visualize fungal RNA uptake. RNA Tagging: Methods and Protocols. 2020:215-25.

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