馬帥，北京幹細胞與再生醫學研究院“致一”研究員，必威精装版app西汉姆联 副研究員。優青，科技部重點研發計劃課題負責人。中國科學院青促會會員，入選中國科協“青年人才托舉工程”。主要研究方向為係統衰老生物學研究，利用單細胞測序和基因編輯等技術開展係統水平衰老、衰老相關疾病以及衰老幹預的新型分子機製的挖掘與解析。以（共）通訊/第一作者在Cell、Cell Stem Cell、Cell Research、Nature Cell Biology、Nature Aging、The Innovation等雜誌上發表多篇研究論文。代表性成果獲2024年度“中國生命科學十大進展”、2020年度“中國科學十大進展”及“中國生命科學十大進展” 、2020及2022年度Cell Press最受歡迎中國論文，作為主要貢獻者之一獲2020年度“中國科學院傑出科技成就獎”、 2024年度北京市自然科學二等獎。現任中國遺傳學會衰老遺傳學分會委員、中國老年醫學學會基礎與轉化醫學分會委員、中國老年學和老年醫學學會抗衰老分會委員、中國衰老標誌物研究聯合體（ABC）委員。

圍繞機體係統衰老的生物學研究，通過齧齒類和靈長類研究模型體係，利用單細胞測序等技術，開展衰老、衰老相關疾病及其幹預的新型分子機製的挖掘與解析。

基金委，優秀青年科學基金項目，項目負責人。項目時間：2024.01-2026.12

基金委，麵上基金項目，項目負責人。項目時間：2023.01-2026.12

基金委，青年科學基金項目，項目負責人。項目時間：2021.01-2023.12

科技部，國家重點研發計劃，課題組長。項目時間：2022.12-2027.11

科技部，國家重點研發計劃，課題骨幹。項目時間：2018.12-2022.12

1. Ma S^#, Ji Z^#, Zhang B^#, Geng L^#, Cai Y^#, Nie C^#, Li J^#, Zuo Y^#, Sun Y^#, Xu G^#, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell, 2024. doi:10.1016/j.cell.2024.10.019.
2. Ma S^#, Sun S^#, Geng L^#, Song M^#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI*, Zhang W*, Qu J*, Liu GH*. Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging. Cell, 2020. 180(5): 984-1001.
3. Yang Y^#, Lu X^#, Liu N^#, Ma S^#, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhang X, Zhu G, Song W, Horvath S, Rodriguez Esteban C, Song M, Wang S, Zhao G, Li W, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Metformin decelerates aging clock in male monkeys. Cell, 2024. 187(22):6358-6378.
4. Ma S^#, Wang S^#, Ye Y^#, Ren J^#, Chen R^#, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell, 2022. 29(6): 990-1005. e10.
5. Ma S^#, Sun S^#, Li J^#, Fan Y^#, Qu J^#, Sun L^#, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Research, 2020. 31(4): 415-432.
6. Ma S^#, Chi X^#, Cai Y^#, Ji Z^#, Wang S*, Ren J*, Liu GH*. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science, 2023.  doi:10.1146/annurev-biodatasci-020722-120642.
7. Ma S^#, Wu Q, Hu Y*, Wei F. Patterns and effects of GC3 heterogeneity and parsimony informative sites on phylogenetic tree of genes. Gene, 2018. 655: 56-60.
8. Wang S^#, Yao X^#, Ma S^#, Ping Y^#, Fan Y^#, Sun S^#, He Z^#, Shi Y^#, Sun L^#, Xiao S^#, Song M^#, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature Cell Biology, 2021. 23(12), 1314-1328.
9. Wang Q^#, Wang X^#, Liu B^#, Ma S^#, Zhang F^#, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Izpisua Belmonte JC, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging, 2024. 4(3): 396-413.
10. Sun S^#, Ma S^#, Cai Y^#, Wang S^#, Ren J^#, Yang Y^#, Ping J, Wang X, Zhang Y, Yan H, Li W, Concepcion Rodriguez Esteban, Yu Y, Liu F, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body, The Innovation, 2023. 5(1): 100380.
11. Lu H^#, Jing Y^#, Zhang C^#, Ma S^#, Zhang W^#, Huang D, Zhang B, Zuo Y, Qin Y, Liu GH*, Yu Y*, Qu J*, Wang S*. Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein & Cell, 2024. 15(5): 364-384.
12. Hu Q^#, Zhang B^#, Jing Y^#, Ma S^#, Hu L^#, Li J, Zheng Y, Xin Z, Peng J, Wang S, Cheng B, Qu J*, Zhang W*, Liu GH*, Wang S*. Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Protein & Cell. 2024. doi:10.1093/procel/pwae017.
13. Li H^#, Zhao W^#, Yang F^#, Qiao Q^#, Ma S^#, Yang K^#, Song S^#, Wang S, Qu J*, Liu GH*, Bao Y*, Zhang W*. Immunosenescence Inventory—a multi-omics database for immune aging research. Nucleic Acids Research, 2024. 53(D1), D1047-D1054.
14. Yan H^#, Wang R^#, Ma S^#, Huang D^#, Wang S^#, Ren J^#, Lu C, Chen X, Lu X, Zheng Z, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: a comprehensive database that records lineage commitment across species, Nucleic Acids Research, 2023. doi.org/10.1093/nar/gkac951.
15. Wang Q^#, Wang X^#, Liu B^#, Ma S^#, Zhang F^#, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Izpisua Belmonte JC, Qu J*, Liu GH*, Zhang W*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research, 2022. 50(D1): D1085-D1090.
16. Hu Y^#, Wu Q^#, Ma S^#, Ma T^#, Shan L, Wang X, Nie Y, Ning Z, Yan L, Xiu Y, Wei F*. Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas. Proc. Natl. Acad. Sci, 2017. 114(5):1081-1086.
17. Sun S^#, Jiang M^#, Ma S*, Ren J*, Liu GH*. Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism, 2024, doi: 10.1016/j.tem.2024.07.009.
18. Yan H^#, Lu C^#, Lan C^#, Wang S^#, Zhang W^#, He Z, Hu J, Ai J, Liu GH*, Ma S*, Zhou Y*, Qu J*. Degeneration Directory: A multi-omics web resource for degenerative diseases. Protein & Cell, 2024. doi:10.1093/procel/pwad066.
19. Zhang Y^#, Zheng Y^#, Wang S^#, Fan Y, Ye Y, Jing Y, Liu Z, Yang S, Xiong M, Yang K, Hu J, Che S, Chu Q, Song M, Liu GH*, Zhang W*, Ma S*, Jing Qu^#. Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging. Protein & Cell, 2023, doi:10.1093/procel/pwac038.
20. Li LZ^#, Yang K^#, Jing Y^#, Fan Y^#, Jiang X, Wang S, Liu GH*, Qu J*, Ma S*, Zhang W*. CRISPR-based screening identifies XPO7 as a positive regulator of senescence, Protein & Cell, 2023. doi:10.1093/procel/pwad012.
21. Chu Q^#, Liu F^#, He Y^#, Jiang X^#, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein & Cell, 2022. doi:10.1007/s13238-021-00898-9.