陳敏，女，博士，副研究員，幹細胞與生殖生物學國家重點實驗室性別決定與性別分化研究組成員。2007年畢業於中科院必威在线网址 ，獲理學博士學位，研究方向為性腺生物學。2011年到2014年在中科院動物所做博士後研究，2014年加入性別決定與性別分化研究組工作，2022年晉升為副研究員。

　　性腺體細胞和生殖細胞的分化調控

　　國家自然科學基金麵上項目（32170855），2022-2025，主持

　　國家自然科學基金青年科學基金項目（31601193），2017-2019，主持

　　國家重點研發計劃（2018YFC1004200），2018-2021，項目骨幹

1. Chen M^#, Dong F^#, Chen M, Shen Z, Wu H, Cen C, Cui X, Bao S, Gao F. PRMT5 regulates ovarian follicle development by facilitating Wt1 translation. Elife. 2021 Aug 27;10:e68930. doi: 10.7554/eLife.68930.
2. Chen M^#, Long X^#, Chen M^#, Hao F, Kang J, Wang N, Wang Y, Wang M, Gao Y, Zhou M, et al. Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. Cell Rep. 2022 Nov 1;41(5):111587. doi: 10.1016/j.celrep.2022.111587.
3. Dong F^#, Chen M^#, Chen M, Jiang L, Shen Z, Ma L, Han C, Guo X, Gao F. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. Front Cell Dev Biol. 2021 May 21;9:673258. doi: 10.3389/fcell.2021.673258.
4. Chen M^#, Chen M^#, Chen S, Zhou J, Dong F, Shen Z, Wu H, Cui X, Gao F. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell, Oxid Med Cell Longev, 2019 Sep 5;2019:8030697. doi: 10.1155/2019/8030697.
5. Chen M^#, Zhang L^#, Cui X, Lin X, Li Y, Wang Y, Wang Y, Qin Y, Chen D, Han C, Zhou B, Huff V, Gao F. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Development, 2017 Jan 1,144(1):44-53. doi: 10.1242/dev.144105.
6. Zhang L^#, Chen M^#, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation, Proc Natl Acad Sci U S A., 2015 Mar 31,112(13):4003-8. doi: 10.1073/pnas.1422371112.
7. Chen M^#, Li S^#, Liu S^#, Zhang Y^#, Cui X, Lv L, Liu B, Zheng A, Wang Q, Duo S, Gao F. Infection of SARS-CoV-2 causes severe pathological changes in mouse testis. J Genet Genomics. 2023 Feb;50(2):99-107. doi: 10.1016/j.jgg.2022.11.011. Epub 2022 Dec 6.
8. Chen M, Cen C, Wang N, Shen Z, Wang M, Liu B, Li J, Cui X, Wang Y, Gao F. The functions of Wt1 in mouse gonad development and somatic cells differentiation. Biol Reprod. 2022 Jul 25;107(1):269-274. doi: 10.1093/biolre/ioac050.
9. Cen C^#, Chen M^#, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F. Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. Biol Reprod. 2020 Jun 23;103(1):60-69. doi: 10.1093/biolre/ioaa042.
10. Chen M, Wang X, Wang Y, Zhang L, Xu B, Lv L, Cui X, Li W, Gao F. Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. Biol Reprod. 2014 Apr 3;90(4):71. doi: 10.1095/biolreprod.113.114702. Print 2014 Apr.
11. Liu W, Chen M, Liu C, Wang L, Wei H, Zhang R, Ren Z, Chen Y, Luo M, Zhao J, Jiang H, Gao F, Li W. Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells. Autophagy. doi.org/10.1080/15548627.2022.2094671.
12. Shen Z, Chen M, Gao Y, Dong F, Cen C, Wu H, Wang N, Cui X, Han C, Gao F. The function of Foxo1 in spermatogonia development is independent of PI3K/PTEN signaling. FASEB J. 2022 Oct;36(10):e22522. doi: 10.1096/fj.202200640RR.
13. 13 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX. The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2. Biol Reprod. 2013 Mar 7;88(3):56. doi: 10.1095/biolreprod.112.105379. Print 2013 Mar.
14. Chen M, Cai H, Yang JL, Lu CL, Liu T, Yang W, Guo J, Hu XQ, Fan CH, Hu ZY, Gao F, Liu YX. Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells. Endocrinology. 2008 Oct;149(10):4871-82. doi: 10.1210/en.2007-1093. Epub 2008 Jun 5.
15. Chen M, Yuan JX, Shi YQ, Zhang XS, Hu ZY, Gao F, Liu YX. Effect of 43 degrees treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells. Asian J Androl. 2008 May;10(3):474-85. doi: 10.1111/j.1745-7262.2008.00391.x.