魏妥，研究員，博士生導師。博士畢業於中國科學院大學/國家納米科學中心及法國艾克斯-馬賽大學；2015-2021年先後於美國哈佛醫學院波士頓兒童醫院、麻省理工學院及美國德克薩斯大學西南醫學中心從事博士後研究工作。2021年9月加入必威精装版app西汉姆联 幹細胞與生殖生物學國家重點實驗室，成立納米技術與藥物遞送研究組。研究組致力於研發安全、高效的納米遞送載體，應用於癌症、遺傳類等重大疾病的治療。已在Nat Nanotechnol., Nat Commun., Adv Mater.等國際知名雜誌發表40餘篇學術論文，被引7000餘次，H指數為33（穀歌學術）。已申請國內外發明專利15項（已授權9項）。

課題組麵向人類重大致死性疾病（如癌症、遺傳類疾病等）治療中的關鍵科學問題，運用化學、材料學、生物學、醫學等多學科交叉，設計研發新型納米遞送技術平台，用以高效、特異性地遞送小分子藥物或生物大分子（包括RNA、蛋白質、基因編輯係統等），擴展並深化其生物醫學領域的應用，主要研究方向：

1. 器官或細胞靶向型脂質納米遞送係統研發；
2. 新型基因編輯遞送係統研發及基因編輯治療研究；
3. 針對重大疾病（如腫瘤、代謝類疾病、遺傳病等）的靶向基因治療研究。

1. Luo Z, Lin Y, Meng Y, Li M, Ren H, Shi H, Cheng Q*, Wei T*. Spleen-Targeted mRNA Vaccine Doped with Manganese Adjuvant for Robust Anticancer Immunity In Vivo. ACS Nano. 2024, doi: 10.1021/acsnano.4c09902.
2. Fei Y, Yu X, Liu P, Ren H, Wei T*, Cheng Q*. Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model. Adv Mater. 2024, doi: 10.1002/adma.202409812.
3. Lin Y, Cheng Q*, Wei T*. Surface Engineering of Lipid Nanoparticles: Targeted Nucleic Acid Delivery and Beyond. Biophys Rep. 2023, 9(5): 255-278. (Invited Review)
4. Wei T#, Sun Y#, Cheng Q#, Chatterjee S, Traylor Z, Johnson LT, Coquelin ML, Wang J, Torres MJ, Lian X, Wang X, Xiao Y, Hodges CA, Siegwart DJ. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nat Commun. 2023, 14(1):7322.
5. Zong Y, Lin Y, Wei T*, Cheng Q*. Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy. Adv Mater. 2023, https://doi.org/10.1002/adma.202303261.
6. Wei T*, Tao W*, Cheng Q*. Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery. Life Medicine. 2022, https://doi.org/10.1093/lifemedi/lnac004.
7. Wei T#, Cheng Q#, Min YL, Olson EN, Siegwart DJ*. Systemic nanoparticle delivery of CRISPR/Cas9 ribonucleoproteins for effective tissue-specific genome editing. Nat Commun. 2020, 11(1):3232. (ESI高被引論文)
8. Cheng Q#, Wei T#, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ*. Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing. Nat Nanotechnol. 2020, 15(4):313. (ESI高被引論文)
9. Wei T, Cheng Q, Farbiak L, Anderson DG*, Langer R*, Siegwart DJ*. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for in Vivo CRISPR/Cas-Based Genome Editing. ACS Nano. 2020, 14(8):9243.(Invited Review)
10. Liu J#, Wei T#, Zhao J, Huang Y, Deng H, Kumar A, Wang C, Liang Z, Ma X*, Liang X-J*. Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Biomaterials. 2016, 91:44.
11. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X-J*, Rocchi P, Peng L*. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proc Natl Acad Sci U S A. 2015, 112(10):2978.
12. Wei T#, Liu J#, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang X-J*. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo. Nano Lett. 2013, 13(6):2528.

（#共同第一作者, *通訊作者）