李天達 博士 必威精装版app西汉姆联 副研究員。

　　中國科學院青年創新促進會會員/生命分會副會長，中國細胞生物學學會科普委員會副主任委員，北京婦產學會京津冀胚胎學分會顧問委員，中國科普作家協會會員。

工作經曆：

　　2012年-2014年 必威精装版app西汉姆联 博士後；2014年-2020年 必威精装版app西汉姆联 助理研究員；2020年-今 必威精装版app西汉姆联 副研究員。

　　研究成果：1.首次證明大鼠胚胎幹細胞具有四倍體補償能力並獲得健康個體，證實最高等級的多能性可以在不同物種間的幹細胞上建立。2.通過提高Primed狀態人胚胎幹細胞的抗凋亡能力證明其具有異種嵌合的能力，為開展人類胚胎幹細胞異種嵌合研究提供了方法和思路。3.首次獲得大鼠孤雄單倍體胚胎幹細胞，證明具有替代精子與卵母細胞“受精”並產生健康大鼠的能力，快速獲得基因修飾的大鼠模型。相關成果在Nature Biotechnology, Cell Stem Cell, PNAS, Cell Research等國際刊物上發表研究論文二十餘篇，其中第一（或共同第一）作者十餘篇。獲得國家自然基金青年項目支持，國家重點研發計劃（項目骨幹）等項目支持。

　　哺乳動物幹細胞多能性獲得、維持及發育潛能的調控並致力於開展幹細胞異種嵌合和體內器官再造相關研究。

1. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis.Wang, Xuepeng^#; Li, Tianda^#; Cui, Tongtong^#; Yu, Dawei^#; Liu, Chao^#; Jiang, Liyuan; Feng, Guihai; Wang, Lei; Fu, Rui; Zhang, Xinxin; Hao, Jie; Wang, Yukai; Wang, Liu; Zhou, Qi; Li, Wei; Hu, Baoyang Cell Res, 2018, 28(1): 126-129
2. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Li, Tian-Da^#; Feng, Gui-Hai^#; Li, Yu-Fei^#; Wang, Mei^#; Mao, Jun-Jie; Wang, Jia-Qiang; Li, Xin; Wang, Xue-Peng; Qu, Bin; Wang, Le-Yun; Zhang, Xin-Xin; Wan, Hai-Feng; Cui, Tong-Tong; Wan, Cong; Liu, Lei; Zhao, Xiao-Yang; Hu, Bao-Yang; Li, Wei; Zhou, Qi^* Proc Natl Acad Sci U S A, 2017, 114(45): 11974-11979
3. Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon. Li, Tianda^#; Shuai, Ling^#; Mao, Junjie^#; Wang, Xuepeng; Wang, Mei; Zhang, Xinxin; Wang, Leyun; Li, Yanni; Li, Wei; Zhou, Qi Sci Rep, 2016, 6: 33225-33225
4. Genetic modification and screening in rat using haploid embryonic stem cells. Li, Wei^#; Li, Xin^#; Li, Tianda^#; Jiang, Ming-Gui^#; Wan, Haifeng; Luo, Guan-Zheng; Feng, Chunjing; Cui, Xiaolong; Teng, Fei; Yuan, Yan; Zhou, Quan; Gu, Qi; Shuai, Ling; Sha, Jiahao; Xiao, Yamei; Wang, Liu; Liu, Zhonghua; Wang, Xiu-Jie; Zhao, Xiao-Yang; Zhou, Qi^* Cell Stem Cell, 2014, 14(3): 404-414
5. Generation of transgenic rats through induced pluripotent stem cells. Jiang, Ming-Gui^#; Li, Tianda^#; Feng, Chunjing^#; Fu, Rui; Yuan, Yan; Zhou, Quan; Li, Xin; Wan, Haifeng; Wang, Liu; Li, Wei; Xiao, Yamei; Zhao, Xiao-Yang; Zhou, Qi J Biol Chem, 2013, 288(38): 27150-27158
6. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Li, Wei^#; Teng, Fei^#; Li, Tianda; Zhou, Qi^* Nature Biotechnology, 2013, 31(8): 684-686
7. Generation of tripotent neural progenitor cells from rat embryonic stem cells. Wang, Zhenkun^#; Sheng, Chao^#; Li, Tianda^#; Teng, Fei; Sang, Lisi; Cao, Fenglin; Wang, Ziwei; Zhu, Wanwan; Li, Wei; Zhao, Xiaoyang; Liu, Zhonghua; Wang, Liu; Zhou, Qi J Genet Genomics, 2012, 39(12): 643-651
8. Derivation of germline competent rat embryonic stem cells from DA rats. Li, Tianda^#; Zhao, Xiao-Yang^#; Teng, Fei^#; Li, Xin; Jiang, Minggui; Li, Wei; Wang, Xuepeng; Wang, Jialiang; Liu, Lei; Liu, Zhonghua; Wang, Liu; Zhou, Qi^* Journal of Genetics and Genomics, 2012, 39(11): 603-606

(^* Corresponding author, ^# Equal contribution)