郝捷，博士，研究員，必威精装版app西汉姆联 國家幹細胞資源庫主任。2004年獲西北農林科技大學理學學士學位，2010年獲中國科學院理學博士學位，2012年必威精装版app西汉姆联 博士後出站並加入必威精装版app西汉姆联 工作。作為通訊/第一作者（含共同）在Cell Research等雜誌發表文章60餘篇，參編著作6部；主持或參與20餘項國家及省部級科研項目，獲授權發明專利20餘項，牽頭製定國內外標準30餘項，獲國家及省部級獎勵10餘項。基於工作進展，已參與開展十餘項國家兩委局備案的幹細胞臨床研究，獲得五項國家藥品監督管理局批準的I/II期藥物臨床試驗批件，多項工作實現科技成果轉化。獲得抗擊新冠肺炎疫情全國三八紅旗手等多項榮譽稱號，所帶團隊也獲得全國五一巾幗標兵崗、中國科學院先進集體等榮譽稱號。

主要從事新型幹細胞與工具細胞等創新細胞資源研發與幹細胞藥物研製，致力於構建標準化的幹細胞資源庫和探索幹細胞成藥及科技創新支撐路徑。

主持或參與中國科學院關鍵核心技術攻堅先導專項、國家重點研發計劃、中國科學院重點部署項目等。

1. Song D#, Li Z#, Sun F#, Wu K#, Zhang K, Liu W, Liu K, An B, Wang Z, Zhao T, Chen H, Xiao L, Wang L, Xie L, Li W, Peng L, Hao J*, Wu J*, Dai H*. Optimized administration of human embryonic stem cell-derived immunity-and-matrix regulatory cells for mouse lung injury and fibrosis. Stem Cell Res Ther. 2024 Oct 8;15(1):344.
2. Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*.Requirements for human natural killer cells. Cell Prolif. 2024 May;57(5):e13588.
3. Peng Y#, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H*, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif. 2024 Mar;57(3):e13556.
4. Huang L#, Zhang S#, Wu J#, Guo B#, Gao T, Shah SZA, Huang B, Li Y, Zhu B, Fan J, Wang L, Xiao Y, Liu W, Tian Y, Fang Z, Lv Y, Xie L, Yao S, Ke G, Huang X, Huang Y, Li Y, Jia Y, Li Z, Feng G, Huo Y, Li W, Zhou Q, Hao J*, Hu B*, Chen H*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduct Target Ther. 2023 Nov 1;8(1):417.
5. Ji T#, Niu S#, Fang M#, Xu L#, Wang X, Wu J, Xu F, Zhang M. Niu R, Wu J, Wang L, Li Z, Yang Y, Hao J*, Li W*, Hu Z*, Zhou Q*. Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell therapies. Cell Proliferation 56. Cell Prolif. 2023 May;56(5):e13471.
6. Guo B#, Duan Y#, Li Z#, Tian Y, Cheng X, Liang C, Liu W, An B, Wei W, Gao T, Liu S, Zhao X, Niu S, Wang C, Wang Y, Wang L, Feng G, Li W, Hao J*, Gu Q*, Zhou Q*, Wu J*. High-Strength Cell Sheets and Vigorous Hydrogels from Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells. ACS Appl Mater Interfaces. 2023 Jun 14;15(23):27586-27599.
7. Gao T#, Zhao X#, Hao J#, Tian Y, Ma H, Liu W, An B, Sun F, Liu S, Guo B, Niu S, Li Z, Wang C, Wang Y, Feng G, Wang L, Li W, Wu J*, Guo M*, Zhou Q*, Gu Q*. A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells. Mater Today Bio. 2023 May 5:20:100662.
8. Zhou H#, Cui Z#, Wang H#, Gao T, Wang L, Wu J, Xiong Z*, Hao J*, Zhao M*. The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy. Stem Cell Res Ther. 2022 Jun 7;13(1):240.
9. Yang S#, Liu P#, Gao T#, Song D, Zhao X, Li Y, Wu J, Wang L, Wang Z*, Hao J*, Wang C*, and Dai H*. Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes. Stem Cell Res Ther. 2022 Apr 12;13(1):163.
10. Wang L#, Cao J#, Peng Y#, Fu B#, Jin Z, Hu Y, Wu W, Xiang AP, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A*, Stacey G*, Zhao T*, Hao J*. Human retinal pigment epithelial cells. Cell Prolif. 2022 Apr;55(4):e13153.
11. Zhang B, Wu X, Zi G, He L, Wang S, Chen L, Fan Z, Nan X, Xi J, Yue W, Wang L, Wang L, Hao J*, Pei X*, Li Y*. Large-scale generation of megakaryocytes from human embryonic stem cells using transgene-free and stepwise defined suspension culture conditions. Cell Prolif. 2021 Apr;54(4):e13002.
12. Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T, Peng Y*, Zhou Q*, Zhao T*. Developing standards to support the clinical translation of stem cells. Stem Cells Transl Med. 2021 Nov;10 Suppl 2(Suppl 2):S85-S95.
13. Wu J#, Song D#, Li Z#, Guo B#, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang N, Zhou Q, Wang L*, Hu B, Dai H*, Hao J*. Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis. Cell Res. 2020 Sep;30(9):794-809.
14. Xing D, Wu J, Wang B, Liu W, Liu W, Zhao Y, Wang L, Li JJ, Liu A, Zhou Q, Hao J*, Lin J*. Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. Int J Rheum Dis. 2020 Apr 21.
15. Li Z#, Wu J#, Wang L#, Han W, Yu J, Liu X, Wang Y, Zhang Y, Feng G, Li W, Stacey GN, Gu Q, Hu B, Wang L, Zhou Q*, Hao J*. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. Cell Death Dis. 2019 Oct 10;10(10):763.
16. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460.
17. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord and chorionic plate under serum-free condition. Stem Cell Res Ther. 2019 Jan 11;10(1):19.
18. Li X#, Ma R#, Gu Q#, Liang L, Wang L, Zhang Y, Wang X, Liu X, Li Z, Fang J, Wu J, Wang Y, Li W, Hu B, Wang L*, Zhou Q*, Hao J*. A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis. 2018 Sep; 9(9): 892.
19. Cao Y#, Sun H#, Zhu H#, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L, Zhou Q, Wang H, Dai C, Ding L, Xu B, Zhou Y, Hao J*, Dai J*, Hu Y*. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 2018 Jul 11; 9(1): 192.
20. Tan Y#, Han P#, Gu Q#, Chen G, Wang L, Ma R, Wu J, Feng C, Zhang Y, Wang L, Hu B, Li W, Hao J*, and Zhou Q*. (2018) Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med. 2018 Jan; 12(1):153-63.
21. Gu Q#, Wang J#, Wang L#, Liu Z, Zhu, W Tan, Y Q, Han W, Wu J, Feng C, Fang J, Liu L, Wang L, Li W, Zhao X, Hu B, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem cell reports. 2017 Jul 11; 9(1): 366-80.
22. Gu Q#, Zhu H#, Chen L, Shuai L, Fang J, Wu J, Liu L, Li W, Dai J, Hao J*, Zhou Q*. Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein cell. 2016 Nov; 7(11): 844-8.
23. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015 Nov 12; 6(1):223.
24. Gu Q#, Hao J#, Lu Y, Wang L, Wallace GG*, Zhou Q*. Three-dimensional bio-printing. Sci China Life Sci. 2015 May; 58(5):411-9.
25. Gu Q#, Hao J#, Hai T, Wang J, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 2014 May; 5(5):338-42.
26. Wang J#, Gu Q#, Hao J#, Bai D, Liu L, Zhao X, Liu Z, Wang L, Zhou Q*. Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):304-11.
27. Wang J#, Gu Q#, Hao J#, Jia Y, Xue B, Jin H, Ma J, Wei R, Hai T, Kong Q, Bou G, Xia P, Zhou Q, Wang L*, Liu Z*. Tbx3 and Nr5α2 play important roles in pig pluripotent stem cells. Stem Cell Rev and Rep. 2013; 9(5):700-8.
28. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell. 2012 Jan; 3(1):71-9.
29. Hai T#, Hao J#, Li W, Jouneau A*, Zhou Q*. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. Cell Reprogram. 2011 Feb; 13(1):47-56.
30. Dai X#, Hao J#, Hai T, Fan Y, Yu Y, Jouneau A, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J Biol Chem. 2010 Oct 1; 285(40):31002-10.