王昱凱，男，博士，副研究員，碩士生導師。

2011年博士畢業於山東大學，隨後加入必威精装版app西汉姆联 從事博士後研究，先後擔任助理研究員、副研究員。主要方向為幹細胞命運調控與神經再生，重點關注帕金森病、腦血管病、阿爾茲海默病的神經修複和治療，相關研究成果以第一或通訊作者（含共同）發表在Cell，Immunity，Cell Proliferation、Advanced Science等刊物共30餘篇。授權國家發明專利7項，國際PCT1項，完成6個專利技術的轉化，牽頭和參與製定團體標準4項、國家標準1項、國際標準1項。

擔任Stroke & Vascular Neurology青年編委，npj Regenerative Medicine，Advanced Science等期刊審稿人，國際標準化組織ISO/TC 276委員會成員。主要工作被Nature、The Scientist雜誌和中央台專題報道，榮獲2019年度“中國生命科學十大進展”。開發的神經細胞產品獲第22屆中國國際高新技術成果交易會“優秀產品獎”，角膜內皮細胞產品入選2023中關村論壇國際技術交易大會“百項新技術新產品榜單”。

　　研究多能幹細胞向特定亞型神經細胞的命運調控和定向分化技術；建立人神經類器官並將其用於疾病建模、藥物篩選；開發神經細胞藥物，用於重大神經係統疾病的替代治療。

國家重點研發計劃“揭榜掛帥”項目，2025-2027，課題負責人

北京市自然科學基金重點研究專題，2023-2027，課題負責人

國家自然基金委麵上基金項目，2020-2023，課題負責人

國家自然基金委青年科學基金項目，2017-2019，課題負責人

中國科學院穩定支持基礎研究領域青年團隊計劃，2022-2027，參加

中國科學院戰略性先導科技專項，2017-2022，參加

1. Gaoying Sun^#; Yukai Wang^#; Man Wang^#; Xinyue Wang; Mingming Tang; Da Li; Jianhuan Qi; Xue Wang; Shujuan Sun; Lei Chen; Weibin An; Ligang Kong; Anqi Suo; Haibo Wang*; Wenwen Liu*; Lei Xu*; Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation, Advanced Science, 2026 Feb;13(7):e05663.
2. Weizheng Liang^#, Guipeng Li^#, Yukai Wang^#, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui*, Wei Chen*. Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents. Cell Proliferation. 2026 Mar;59(3):e70103.
3. Tingting Zhang^#, Da Li^#, Qibiao Guan, Bin An, Yun Sun, Qiang Wang, Yukai Wang*, Baoyang Hu*. Lineage-Biased Neural Stem Cell Grafting Promotes Neuronal Differentiation and Vascular Repair in the Chronic Phase of Stroke. CNS Neurosci Ther. 2026 Jan;32(1):e70701.
4. Jing Liu; Zhimeng Wang; Wenwen Liang; Zhenhao Zhang; Yusen Deng; Xiaowei Chen; Zongren Hou; Yuanzhi Xie; Qi Wang; Yuan Li; Chaobo Bai; Da Li; Fan Mo; Huinan Wang; Dongmei Wang; Junliang Yuan*; Yukai Wang*; Zhao-Qian Teng*; Baoyang Hu*; Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease, Immunity, 2025, 58(7): 1830-1846.E7.
5. Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang*, Baoyang Hu*. Human midbrain organoids enriched with dopaminergic neurons for long- term functional evaluation. Cell Proliferation. 2025 58(7): e70005.
6. Feng L, Li D, Tian Y, Zhao CS, Sun Y, Kou XL, Wu J, Wang L, Gu Q, Li W, Hao J, Hu BY*, Wang YK*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regen Res. 2024, 19(2):458-464.
7. Yu J#, Yu NY#, Tian Y#, Fang YF#, An B, Feng GH, Wu J, Wang L, Hao J, Wang LQ, Zhou Q, Li W*, Wang YK*, Hu BY*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience. 2023, 13, 201
8. Wang YK^#, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JQ, Li TQ, Wang L, Fu BQ, Fu Y, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang P*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Proliferation. 2023 Oct 25: e13563.
9. Wang YK^#, Yu J^#, Zhang TT^#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang P, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu Y, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Proliferation. 2023, Oct 18:e13564.
10. Liang LM^#, Tian Y^#, Feng L^#, Wang CQ^#, Feng GH, Stacey GN, Chang NS, Wu J, Hu BY, Li W, Hao J, Wang L*, Wang YK*. Single‑cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem Cell Research & Therapy. 2022, 13:412
11. Zhao YL^#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223.
12. Sun Y^#, Feng L^#, Liang LM^#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021, Nov;10 Suppl 2(Suppl 2):S31-S40.
13. Liu J^#, Hou ZR^#, Wu J^#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021, Aug;54(8):e13085.
14. Wang YK^#, Zhu WW^#, Wu MH^#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182. 
15. Wang JQ^#, Wang LY^#, Feng GH^#, Wang YK^#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901.
16. He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237.
17. Lu XY^#, Wang YK^#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612.
18. Li X^#, Cu XLi^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292. 
19. Li ZK^#, Wang LB^#, Wang YK^#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128. 
20. Shuai L^#, Wang YK^#, Dong MZ^#, Wang XP^#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337. 
21. Wang LB^#, Cao JN^#, Wang YK^#, Lan TS^#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015.