姓  名: 張 映
學  科: 發育生物學
電話/傳真: +86-10-64807297 / +86-10-64807306
電子郵件: yingzhang@ioz.ac.cn
通訊地址: 北京市朝陽區大屯路甲3號院
中國科學院幹細胞與再生醫學創新研究院大樓 必威精装版app西汉姆联 器官再生與智造全國重點實驗室 100101
更多信息: 生殖工程研究組     

簡曆介紹:

張映,博士,副研究員,碩士生導師。

2007年在北京大學醫學部獲得博士學位。2008年至2010年在北京大學幹細胞中心做博士後研究。現任器官再生與智造全國重點實驗室副研究員,主要從事表觀遺傳修飾與幹細胞多能性相關研究。以第一作者/共同第一作者/通訊作者的身份在Cell Stem Cell、EMBO J、Cancer Res、J Cell Biol、Mol Cancer、Signal Transduct Target Ther、Protein Cell、J Biol Chem、FASEB J等雜誌發表研究論文20餘篇,其中發表在Cell Stem Cell 的為封麵文章,並被Cell 出版社作為Highlight的兩篇文章之一重點報道。

研究領域:

  幹細胞與細胞命運調控

社會任職:

獲獎及榮譽:

承擔科研項目情況:

主持國家自然科學基金麵上項目一項、青年項目一項、作為科研骨幹參與國家重大科學研究計劃一項,重點研發計劃兩項,中國科學院關鍵核心技術攻堅先導專項項目一項。

代表論著:

(#共同第一作者,*通訊作者)

  1. Zhu L#, Xu K#, Ding Y#, Liu K#, Liu J, Hou Z, Niu R, Yang N, Qin H, Hu B, Zhang Y*, Li W*. (2025) Identification and Phylogenetic Characterisation of Novel Adeno-Associated Virus Capsids in Non-Human Primate Tissues. Cell Prolif. Sep 16:e70127.
  2. Li P#, Ying S#, Zou Y#, Wang X, Zhang R, Huang C, Dai M, Xu K, Feng G, Li X, Jiang H, Li Z, Zhang Y*, Li W*, Zhou Q*. (2025) NSun2-Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation. Cell Prolif. May 12:e70058.
  3. Jiang H#, Chen Y#, He Z#, Li J#, Gao Q, Li W, Wei W*, Zhang Y*. (2023) Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition. Biochem Biophys Res Commun. Oct 27;686:149149.
  4. Ying S#, Li P#, Wang J#, Chen K#, Zou Y, Dai M, Xu K, Feng G, Zhang C, Jiang H, Li W, Zhang Y*, Zhou Q*. (2023) tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis. Signal Transduct Target Ther. Apr 3;8(1):144. (封麵文章)
  5. He Z#, Yuan X#, Lu Z#, Li Y#, Li Y, Liu X, Wang L, Zhang Y*, Zhou Q*, Li W*. (2022) Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts. Fundamental Research. 2(1):37-47. (封麵文章)
  6. Jiao G#, Wang C#, Chen Y#, Dai M, Zhang Y*, Li W*. (2022) Enhancing targeted transgene knock-in by donor recruitment. Cell Prolif. Jan;55(1):e13163.
  7. Mao Y#, Wang L#, Zhong B#, Yang N#, Li Z, Cui T, Feng G, Li W, Zhang Y*, Zhou Q*. (2021) Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors. Cell Prolif. Aug;54(8):e13090.
  8. Li Y#, Guo L#, Ying S#, Feng GH, Zhang Y*. (2020) Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Prolif. Oct;53(10):e12903.
  9. Mao J#, Xu K#, Han J#, Feng G, Zhang Y*, Li W*. (2020) Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein Cell. Jun;11(6):452-457.
  10. Li J#, Wang C#, Feng G#, Zhang L#, Chen G, Sun H, Wang J, Zhang Y*, Zhou Q*, Li W*. (2020) Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. Jan;53(1):e12724.
  11. Yuan X#, He Z#, Mao J#, Hu Y#, Liu X, Guo J, Liu Z, Zhang Y*, Li W*, Zhou Q*. (2019) Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction. Cell Discov. May 14;5:26. 
  12. Li Y#, Wang L#, Zhang L#, He Z#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. (2019) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. May 6;218(5):1553-1563.
  13. Chen G#, Zhang D#, Zhang L#, Feng G, Zhang B, Wu Y, Li W, Zhang Y*, Hu B*. (2018) RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun. Jun 18;501(1):259-265.
  14. Zhang W, Feng G, Wang L, Teng F, Wang L, Li W, Zhang Y*, Zhou Q*. (2018) MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation. J Mol Cell Biol. Dec1;10(6):515-526. (Natl Sci Rev雜誌Highlight) 
  15. Zhang Y#, Guo L#, Li Y#, Feng GH, Teng F, Li W, Zhou Q*. (2018) MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer. Mol Cancer. Jan 5;17(1):1. 
  16. Zhang Y#, Cui P#, Li Y#, Feng G, Tong M, Guo L, Li T, Liu L, Li W, Zhou Q*. (2018) Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation. FASEB J. Apr;32(4):1891-1902. 
  17. Zhang Y, Zhou Q*. (2017) A single-cell snapshot of cell-fate decisions. J Biol Chem. Jun 9;292(23):9855-9856.
  18. Zhang Y*, Wang S, Li L*. (2016) EF hand protein IBA2 promotes cell proliferation in breast cancers via transcriptional control of cyclin D1. Cancer Res. Aug 1;76(15):4535-45. 
  19. Zhang Y, Feng GH, Xu K, Wang L, Cui P, Li Y, Wang C, Teng F, Hao J, Wan HF, Tan Y, Wang XJ*, Zhou Q*. (2016) A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection. Sci Rep. Mar 1;6:22380.
  20. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. (2015) m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell. Mar 5;16(3):289-301. (封麵文章)
  21. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. (2013) MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol Chem. Aug 16;288(33):23659-65.
  22. Liu X#, Zhang Y#, Tong M, Liu XY, Luo GZ, Xie DF, Ren SF, Bai DH, Wang L, Zhou Q, Wang XJ*. (2013) Identification of a small compound as a novel inhibitor of the p53 transcription factor. Acta Pharmacol Sin. Jun;34(6):805-10.
  23. Zhang Y, Zhang H, Liang J, Yu W, Shang Y*. (2007) SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. EMBO J. Jun 6;26(11):2645-57.

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