本課題組致力於幹細胞分化與再生過程中所需的營養與代謝編程研究。代謝是維持組織器官中細胞生長和功能的核心，也是生命係統能量供給的主要來源。代謝組直接與表型相關聯，可反映機體的生理或病理狀態。作為開創幹細胞代謝領域的青年學者之一，黃仕強研究員領導課題組開展了一係列的幹細胞代謝組學研究和分析工作，探討幹細胞分化與再生過程中所需的營養與代謝編程：

（1）構建基於空間代謝組學和體內外3D肌肉等組織模型，通過開發代謝組學，人工智能技術，液相質譜和質譜成像技術，以升級不同細胞類的代謝組學分析逐步實現空間代謝組學，剖析發育與再生的空間代謝規律。分析結果揭示了細胞重編程肌肉衰減、肌肉再生、肌肉鍛煉、妊娠器官與胚胎發育的代謝調控規律。本研究曾被 Nature Medicine, Science 等評述。(Nat Med 2016, Genes Dev 2017, Cell Stem Cell 2019, Adv Sci 2023, Bioanal Chem 2023, Sci Adv 2023, Trends Endocrin Metab 2024, Cell Stem Cell 2024, Cell 2024)

（2）研究幹細胞在再生過程中所需的營養和代謝編程原理。結合基因測序、代謝組學等大數據分析技術，尋找能調控組織再生的關鍵因子。發現 Lin28 等幹細胞因子是通過營養代謝率、表觀遺傳修飾代謝、代謝應激反應，來促進組織發育與組織再生。營養代謝對於細胞命運調控既因既果。本研究曾被 Nature, Science 等評述。(Cell 2011, Science 2012, Cell 2013, Cell Stem Cell 2013, Trends Endocrin Metab 2016, Cell Stem Cell 2021, Cell Prolif 2023, Cell Res 2023)

（3）基於以上研究基礎，為尋找診治肌肉衰減、肌少性肥胖、糖尿病、子癇前期等代謝疾病提供新方案。

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