宋默識，必威精装版app西汉姆联 膜生物學國家重點實驗室研究員。2011年於瑞典卡羅琳斯卡醫學院獲醫學碩士學位，2015年於美國聖路易斯華盛頓大學獲理學博士學位，後於美國斯坦福大學從事心血管方向的博士後研究。2018年初全職加入必威精装版app西汉姆联 ，成立線粒體與疾病研究組並擔任研究組組長。主要從事線粒體調控心髒衰老及相關疾病的機製與幹預研究，解析心髒衰老的分子機製，發現心髒衰老的生物標記物，開發心髒衰老及相關疾病的幹預策略。共發表論文88篇，引用6100餘次。近五年，以 (共同) 通訊或一作身份在Cell、Cell Research (x2)、Advanced Science (x2)、Nature Communications (x2)、Nature Aging (x2)、Nucleic Acids Research (x2)等雜誌發表論文44篇，平均影響因子>18。申請發明專利16項，授權8項。

　　心髒衰老及相關疾病

• 國家重點研發計劃項目青年項目，主持
• 國家自然科學基金重大研究計劃培育項目，主持
• 國家自然科學基金創新研究群體，骨幹
• 中國科學院穩定支持基礎研究領域青年團隊計劃，骨幹
• 北京市自然科學基金傑出青年科學基金項目，主持，已結題
• 國家自然科學基金優秀青年科學基金項目，主持，已結題
• 國家自然科學基金麵上項目，主持，已結題
• 中國科學院A類戰略性先導科技專項子課題，主持，已結題

1. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*.Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury.Adv Sci. 2024.
2. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023 Apr 13;14(3):202-216.
3. Aging Biomarker Consortium, Zhang W, Che Y, Tang X, Chen S, Song M*, Wang L*, Sun A*, Chen H*, Xu M*, Wang M*, Pu J*, Li Z*, Xiao J*, Cao C*, Zhang Y*, Lu Y*, Zhao Y*, Wang Y*, Zhang C*, Shen T*, Zhang W*, Tao L*, Qu J*, Tang Y*, Liu GH*, Pei G*, Li J*, Cao F*. A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement, Life Medicine, Volume 2, Issue 5, October 2023, lnad035.
4. Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med. 2023 Sep;29(9):2162-2165.
5. Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F*, Song M*, Wang J*. Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract. Protein Cell. 2023 Apr 21;14(4):309-313.
6. Ma Y, Liu X, Zhang X, Yu Y, Li Y, Song M*, Wang J*. Efficient Mining of Anticancer Peptides from Gut Metagenome. Adv Sci. 2023 Sep;10(25):e2300107.
7. Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci. 2023 May;66(5):893-1066.
8. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell. 2022 Sep;13(9):676-682.
9. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316.
10. Shen J, Liu GH*, Song M*.Potential approaches for intervening aging. Natl Sci Open, 1 2 (2022) 20220021.
11. Yu Y, Liu B, Liu X, Zhang X, Zhang W, Tian H, Shui G, Wang W, Song M*, Wang J*. Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites. J Genet Genomics. 2022 Jul;49(7):612-623.
12. Chen L, Zhao N, Cao J, Liu X, Xu J, Ma Y, Yu Y, Zhang X, Zhang W, Guan X, Yu X, Liu Z, Fan Y, Wang Y, Liang F, Wang D, Zhao L, Song M*, Wang J*. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes. Nat Commun. 2022 Jun 8;13(1):3175.
13. Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell. 2022 Jun;13(6):454-461.
14. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JJ*, Liu GH*. The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454.
15. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Res. 2021 Apr;31(4):415-432.
16. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021 May 7;49(8):4203-4219.
17. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell. 2021 Feb;12(2):145-151.
18. Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020 Mar 5;180(5):984-1001.e22.
19. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020 Jul;11(7):483-504.
20. Zhang J, Liu GH*, Qu J*, Song M*. Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther. 2020 Aug;27(7-8):309-311.
21. Wang Y, Li Y, He C, Gou B, Song M. Mitochondrial regulation of cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1853-1864.
22. Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell. 2019 Jun;10(6):417-435.
23. Zhang W#, Song M#, Qu J, Liu GH. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018 Sep 14;123(7):773-786.
24. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018 Nov;9(11):945-965.
25. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017 Dec 5;26(6):872-883.e5.
26. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 4;350(6265):aad2459.
27. Song M, Dorn GW 2nd. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab. 2015 Feb 3;21(2):195-205.
28. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-286.
29. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015 Jul 31;117(4):346-51.
30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res. 2014 Jul 18;115(3):348-53.