滕兆乾，博士，研究員，博士生導師，幹細胞與腦損傷修複研究組組長。

2005年博士畢業於必威精装版app西汉姆联 ，先後在中國農業大學、美國新墨西哥大學醫學院、路易斯安那州立大學健康科學中心以及約翰·霍普金斯大學醫學院做博士後與Research Associate。主要從事神經再生、腦損傷、神經退行性疾病與精神疾病方麵的研究，研究成果發表在Nature Neuroscience、Immunity、Molecular Psychiatry、Cell、Cell Stem Cell、Stem Cell Reports、Glia等國際學術期刊上。

研究工作主要集中在腦損傷、神經退行性疾病與精神疾病的致病機理以及神經再生修複策略的應用研究。研究組的主要研究方向包括：（1）神經再生障礙的細胞與分子機製；（2）小膠質細胞在疾病發生發展過程中表型轉化與靶向幹預；（3）人小膠質細胞與神經元的定向分化與功能增強；（4）基因/細胞藥物的開發與應用。

承擔國家重點研發計劃、中國科學院A類戰略性先導科技專項、國家自然科學基金、北京市自然科學基金項目/課題等。

1. Liu C^#, Shao FH^#, He XC^#, Du HZ, Liu CM*, Zhou B*, Teng ZQ*. Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury. Glia. 2025, 73(5):1036-1050.
2. Liu J^#, Wang Z^#, Liang W, Zhang Z, Deng Y, Chen X, Hou Z, Xie Y, Wang Q, Li Y, Bai C, Li D, Mo F, Wang H, Wang D, Yuan J*, Wang Y*, Teng ZQ*, Hu B*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity. 2025, 58(7):1830-1846.
3. Li CP^#, Wu S^#, Sun YQ, Peng XQ, Gong M, Du HZ, Zhang J, Teng ZQ*, Wang N*, Liu CM*. Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. Cell Reports Medicine. 2024, 5(5):101554.
4. Liu C^#, Gao X^#, Shi RX^#, Wang YY, He XC, Du HZ, Hu B, Jiao J, Liu CM, Teng ZQ*. Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice. Cell Proliferation. 2023, 56(9):e13439.
5. Liu PP^#, Dai SK^#, Mi TW^#, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng ZQ*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Molecular Medicine. 2022, 14(12):e15795.
6. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, He BD, He XC, Du HZ, Yang HC, Tang Y, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning, and memory. Molecular Psychiatry. 2022, 27(7):2999-3009.
7. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ*, Liu CM*. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Reports. 2021, 22 (10): e52023.
8. Liu C^#, Dai SK^#, Shi RX, He XC, Wang YY, He BD, Sun XW, Du HZ, Liu CM*, Teng ZQ*. Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration. Glia. 2021, 69 (5): 1292-1306.
9. Wang ZM, Liu C, Wang YY, Deng YS, He XC, Du HZ, Liu CM*, Teng ZQ*. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell Death Discovery. 2020, 6 (1): 1-11.
10. Cheng Y^#, Wang ZM^#, Tan W^#, Wang X^#, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D*, Teng ZQ*, Jin P*. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience. 2018, 21(12): 1689-1703.
11. Chen R^#, Zhang J^#, Fan N^#, Teng ZQ^#, Wu Y^#, Yang H, Tang YP, Sun H, Song Y, Chen C*. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell. 2013, 155(5): 1154-1165.
12. Liu C^#, Teng ZQ^#, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X*. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5): 433-44.

專利情況：

1. 發明名稱：一種高效感染原代小膠質細胞的重組突變腺相關病毒及其相關生物材料。發明人：滕兆乾；何炫程；劉長梅；杜洪震。專利號：ZL 2021 1 0021870.7。授權公告日：2022年05月10日。
2. 發明名稱：一種多能幹細胞誘導產生小膠質細胞的方法及試劑盒。發明人：滕兆乾；李騫；劉長梅；杜洪震。專利號：ZL 2019 1 0558177.6。授權公告日：2021年10月29日。