張曉明，男，博士，二級研究員，博士生導師；必威精装版app西汉姆联 “表觀遺傳與抗病毒免疫研究組”組長。中國科學院特聘研究骨幹，中國科學院大學崗位教師。國家高層次人才項目（青年）、國家自然科學基金委“優秀青年項目”與“傑出青年項目”項目獲得者，中國科學院引才計劃評估優秀獲得者、科技部重點研發計劃專項首席科學家。中國昆蟲學會理事、媒介昆蟲與病原互作專委會副主任，中國植物病理學會病毒專業委員會、中國昆蟲學會昆蟲比較免疫與互作專業委員會委員。

2001年在南開大學獲得學士學位。2007年於北京大學獲得博士學位。

2008-2014年在加州大學河濱分校進行博士後研究。

聚焦RNA在機體抗性免疫反應中的作用，解析動植物內非編碼RNA的調控機理和免疫功能，揭示蛋白編碼RNA的發生機製和抗性功能，並嚐試進行RNA農藥等RNA相關產品的開發與應用。相關研究在 Cell Host & Microbe、Science Advances，Nature Communications 和 The Plant Cell 等期刊發表。

以解析動植物對病原和蟲媒的抗性機製為目的，本研究組的研究重點為：1）非編碼RNA在機體抗性反應過程中功能；2）細胞器互作對機體抗性反應的意義。

1. Huang, J., Du, J., Liu, Y., Lu, L., Xu, Y., Shi, J., Liu, Q., Li, Q., Liu, Y., Chen, Y., Du, M., Zhao, Y., Huo, L., Wang, W., Ding, C., Wei, L., Wu, J., Yuan, Y.-W., Chen, J., Li, R., Cui, F.* and Zhang, X*. (2025). RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites. Nature communications 16, 1953.
2. Zhao, W., Li, Q., Sun, M., Luo, L., Zhang, X.,* and Cui, F*. (2025). Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection. PLoS Pathogens 21, e1012789.
3. Song, S., Wang, Q., Huo, L., Xie, L., Chen, J., Cui, H., Dai, Z., Kang, J., Li, Y., Guo, W., Chen, J., Kang, L.* and Zhang, X*. (2024). The phytoplasma (Candidatus Phytoplasma arecae) is the crucial pathogen to cause areca palm yellow leaf disease. Science bulletin.
4. Huang, J., Zhao, Y., Liu, S., Chen, Y., Du, M., Wang, Q., Zhang, J., Yang, X., Chen, J* and Zhang, X*. (2024). RH20, a phase-separated RNA helicase protein, facilitates plant resistance to viruses. Plant science 347, 112176.
5. Li, Q#., Liu, Y#., and Zhang, X*. (2024). Biomolecular condensates in plant RNA silencing: insights into formation, function, and stress responses. The Plant cell, 36(2), 227–245.
6. Wu, J#., Zhang, Y#., Li, F#., Zhang, X#., Ye, J., Wei, T., Li, Z., Tao, X., Cui, F., Wang, X., Zhang, L., Yan, F., Li, S., Liu, Y., Li, D., Zhou, X* and Li, Y*. (2024). Plant virology in the 21st century in China: Recent advances and future directions. Journal of integrative plant biology, 66(3), 579–622.
7. Zhou, W., Huang, J., Yang, X*., and Zhang, X*. (2024). Detection of dsRNA with Fluorescence In Situ Hybridization (FISH). Methods Mol Biol 2771, 35-38.
8. Chen, X., Li, W.W., Gao, J., Wu, Z., Du, J., Zhang, X., and Zhu, Y.X. *. (2024). Arabidopsis PDLP7 modulated plasmodesmata function is related to BG10-dependent glucosidase activity required for callose degradation. Science bulletin.
9. Lu, T., Ji, Y., Chang, M., Zhang, X., Wang, Y., and Zou, Z. (2024). The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus. BMC Biology 22, 7.
10. Chen, J#., Liu, Y#., Liu, M#., Guo, W#., Wang, Y#., He, Q#., Chen, W., Liao, Y., Zhang, W., Gao, Y., Dong, K., Ren, R., Yang, T., Zhang, L., Qi, M., Li, Z., Zhao, M., Wang, H., Wang, J., Qiao, Z., Li, H., Jiang, Y., Liu, G., Song, X., Deng, Y., Li, H., Yan, F., Dong, Y., Li, Q., Li, T., Yang, W., Cui, J., Wang, H., Zhou, Y., Zhang, X., Jia, G., Lu, P., Zhi, H., Tang, S* and Diao, X*. (2023). Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet. Nature Genetics 55, 2243-2254.
11. Huang, J#., Zhou, W#., Zhang, X* and Li, Y*. (2023). Roles of long non-coding RNAs in plant immunity. PLoS pathogens, 19(5), e1011340.
12. Du, J., Liu, Y., Lu, L., Shi, J., Xu, L., Li, Q., Cheng, X., Chen, J* and Zhang, X*. (2022). Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana. BMC plant biology, 22(1), 576.
13. Liu, Y#., Rao, J#., Mi, Y#., Chen, L., Feng, L., Li, Q., Geng, J., Yang, X., Zhan, X., Ren, L., Chen, J* and Zhang, X*. (2022). SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cells. Frontiers in immunology, 13, 1008084.
14. Liu, N#., Xu, Y#., Li, Q., Cao, Y., Yang, D., Liu, S., Wang, X., Mi, Y., Liu, Y., Ding, C., Liu, Y., Li, Y., Yuan, Y. W., Gao, G., Chen, J*., Qian, W* and Zhang, X*. (2022). A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell host & microbe, 30(8), 1124–1138.e8.
15. Cheng, Y., Lu, T., Guo, J., Lin, Z., Jin, Q., Zhang, X* & Zou, Z*. (2022). Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression. Open biology, 12(3), 210307.
16. Li, Q#., Liu, N#., Liu, Q#., Zheng, X., Lu, L., Gao, W., Liu, Y., Liu, Y., Zhang, S., Wang, Q., Pan, J., Chen, C., Mi, Y., Yang, M., Cheng, X., Ren, G., Yuan, Y. W and Zhang, X*. (2021). DEAD-box helicases modulate dicing body formation in Arabidopsis. Science advances, 7(18), eabc6266.
17. Gao, W#., Liu, Y#., Huang, J#., Chen, Y., Chen, C., Lu, L., Zhao, H., Men, S* and Zhang, X*. (2021). MES7 Modulates Seed Germination via Regulating Salicylic Acid Content in Arabidopsis. Plants, 10(5), 903.
18. Liu, Q., Liu, Y., Li, Q., Qian, W and Zhang, X*. (2021). Determining the Phase Separation Characteristics of Plant Proteins. Current protocols, 1(9), e237.
19. Liu, Y#., Gao, W#., Wu, S#., Lu, L., Chen, Y., Guo, J., Men, S and Zhang, X*. (2020). AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis. Plants, 9(3), 362.
20. Zhang, B., Zhao, L., Ning, J., Wickham, J. D., Tian, H., Zhang, X., Yang, M., Wang, X and Sun, J. (2020). miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC biology, 18(1), 184.
21. RNA沉默轉基因技術在植物抗病蟲害研究中的作用 楊美玲; 李琦; 陳佳琦; 張曉明《植物保護》 2020，46(4)：1-6
22. Yang, M#., Xu, Z#., Zhao, W#., Liu, Q., Li, Q., Lu, L., Liu, R*., Zhang, X* and Cui, F*. (2018). Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC plant biology, 18(1), 219. 
23. Zhao, W#., Xu, Z#., Zhang, X., Yang, M., Kang, L*., Liu, R* and Cui, F*. (2018). Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. The New phytologist, 219(3), 1085–1096.
24. Huang, J#., Yang, M#., Lu, L* and Zhang, X*. (2016). Diverse Functions of Small RNAs in Different Plant-Pathogen Communications. Frontiers in microbiology, 7, 1552.
25. Huang, J., Yang, M and Zhang, X*. (2016). The function of small RNAs in plant biotic stress response. Journal of integrative plant biology. 58(4):312-27 14.
26. Zhang, X., Niu, D., Carbonell, A., Wang, A., Lee, A., Tun, V., Wang, Z., Carrington, J. C., Chang, C. E and Jin, H*. (2014). ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. Nature communications, 5, 5468.
27. Zhang, X., Lii, Y., Wu, Z., Polishko, A., Zhang, H., Chinnusamy, V., Lonardi, S., Zhu, J. K*., Liu, R* and Jin, H*. (2013). Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues. Molecular plant, 6(3), 704–715.
28. Zhang, X#., Xia, J#., Lii, Y. E., Barrera-Figueroa, B. E., Zhou, X., Gao, S., Lu, L., Niu, D., Chen, Z., Leung, C., Wong, T., Zhang, H., Guo, J., Li, Y., Liu, R., Liang, W., Zhu, J. K., Zhang, W* and Jin, H*. (2012). Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome biology, 13(3), R20.
29. Zhang, X#., Zhao, H#., Gao, S., Wang, W. C., Katiyar-Agarwal, S., Huang, H. D., Raikhel, N and Jin, H*. (2011). Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Molecular cell, 42(3), 356–366.
30. Zhang, W*., Gao, S., Zhou, X., Chellappan, P., Chen, Z., Zhou, X., Zhang, X., Fromuth, N., Coutino, G., Coffey, M and Jin, H*. (2011). Bacteria-responsive microRNAs regulate plant innate immunity by modulating plant hormone networks. Plant molecular biology, 75(1-2), 93–105. 3
31. Zhang, W*#., Gao, S#., Zhou, X., Xia, J., Chellappan, P., Zhou, X., Zhang, X and Jin, H*. (2010). Multiple distinct small RNAs originate from the same microRNA precursors. Genome biology, 11(8), R81.
32. Chellappan, P., Xia, J., Zhou, X., Gao, S., Zhang, X., Coutino, G., Vazquez, F., Zhang, W* and Jin, H*. (2010). siRNAs from miRNA sites mediate DNA methylation of target genes. Nucleic acids research, 38(20), 6883–6894.
33. Zhou, P., Ren, B., Zhang, X., Wang, Y., Wei, C. H and Li, Y*. (2010). Stable expression of rice dwarf virus Pns10 suppresses the post-transcriptional gene silencing in transgenic Nicotiana benthamiana plants. Acta virologica, 54(2), 99–104.
34. Padmanabhan, C#., Zhang, X# and Jin, H*. (2009). Host small RNAs are big contributors to plant innate immunity. Current opinion in plant biology, 12(4), 465–472.
35. Tsuchisaka, A., Yu, G., Jin, H., Alonso, J. M., Ecker, J. R., Zhang, X., Gao, S and Theologis, A*. (2009). A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana. Genetics, 183(3), 979–1003.
36. Zhang, X., Du, P., Lu, L., Xiao, Q., Wang, W., Cao, X., Ren, B., Wei, C and Li, Y*. (2008). Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. Virology, 374(2), 351–360.  
37. Cao, X., Zhou, P., Zhang, X., Zhu, S., Zhong, X., Xiao, Q., Ding, B and Li, Y*. (2005). Identification of an RNA silencing suppressor from a plant double-stranded RNA virus. Journal of virology, 79(20), 13018–13027.

本實驗室專注於非編碼RNA調控和細胞器互作在表觀遺傳和機體抗性反應過程中功能等前沿領域的研究，歡迎有科研激情並勇於挑戰自我的同學們加入。背景專業需要但不限於分子生物學、細胞生物學、表觀遺傳學、植物學、微生物學等。

科研隊伍

張曉明   研究員，研究組組長

李  琦   副研究員

黃  娟   助理研究員

陳佳琦   科研助理

劉  青   博士後

劉  洋   博士後

宋雙偉   博士後

王  乾   博士研究生

周文玲   博士研究生

劉莎莎   博士研究生

霍梁霄   博士研究生

朱孟傑   博士研究生

王炳婷   博士研究生

劉思佳  博士研究生

柴春蓮   碩士研究生

趙一鳴   碩士研究生

謝立強   碩士研究生

李  玥   碩士研究生

蔡誌豪   碩士研究生

郭宇挺   碩士研究生

楊佳佳   碩士研究生