王震波，男，理學博士，研究員，博士研究生導師，幹細胞與生殖生物學國家重點實驗室生殖細胞與受精研究組組長。主要從事哺乳動物卵泡發育及卵母細胞成熟機理、受精機製研究，相關研究成果已發表SCI論文90餘篇。

教育背景及工作經曆：

2017年1月 – 至今， 必威精装版app西汉姆联 ，研究員。

2013年1月 - 2016年12月，必威精装版app西汉姆联 ，副研究員。

2012年7月 - 2012年12月，必威精装版app西汉姆联 ，助理研究員。

2010年7月 - 2012年6月，必威精装版app西汉姆联 ，博士後。

2004年9月 - 2010年7月，必威精装版app西汉姆联 計劃生育生殖生物學國家重點實驗室獲發育生物學博士學位。

2006年6月 - 2008年6月，加拿大渥太華大學健康研究所，訪問研究生。

2000年9月 - 2004年7月，中國農業大學生物學院，獲理學學士學位。 

1).哺乳動物卵母細胞發生與體外再生。

2).受精機製。

3).生育力維持與重塑。

中國動物學會青年科技獎（2017）

中國科學院青年創新促進會會員（2017）

全國婦幼健康科學技術獎自然科學一等獎（2015）

中國動物學會生殖生物學分會青年科技獎（2015)

國家人口與計劃生育委員會優秀科技成果一等獎（2011）

國家重點研發計劃項目（子課題），2022-2027

國家重點研發計劃項目（子課題），2022-2025

國家自然科學基金麵上項目（82171646），2022-2025

北京市自然科學基金重點研究專題項目（課題），2024-2028

1. Sun SM, Zhao BW, Li YY, Liu HY, Xu YH, Yang XM, Guo JN, Ouyang YC, Weng CJ^#, Guan YC^#, Sun QY^#, Wang ZB^#(2024). Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes. Development. Mar 15; 151(6): dev 202285. 
2. Wang L, Liu C, Li L, Wei H, Wei W, Zhou Q, Chen Y, Meng TG, Jiao R, Wang ZB^#, Sun QY^#, Li W^# (2024). RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles. Adv Sci (Weinh). Jan 19:e2306986.
3. Lei WL, Du Z, Meng TG, Su R, Li YY, Liu W, Sun SM, Liu MY, Hou Y, Zhang CH, Gui Y, Schatten H, Han Z, Liu C, Sun F^#, Wang ZB^#, Qian WP^#, Sun QY^# (2023). SRSF2 is required for mRNA splicing during spermatogenesis. BMC Biol. Oct 23;21(1):231.
4. Liu SL, Zuo HY, Zhao BW, Guo JN, Liu WB, Lei WL, Li YY, Ouyang YC, Hou Y, Han ZM, Wang WZ^#, Sun QY, ^# Wang ZB^# (2023). A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human. iScience. Sep 4;26 (10): 107828.
5. Meng TG, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH^#, Wang ZB^#, Wong CC^#L, Li Z^#, Sun QY^# (2023). NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). Sep;10(27):e2301940.
6. Qiao JY, Zhou Q, Xu K, Yue W, Lei WL, Li YY, Gu LJ, Ouyang YC, Hou Y, Schatten H, Meng TG^#, Wang ZB^#, Sun QY^# (2023). Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress.Development. Jul 15;150(14):dev201398.
7. Zhang Q, Hao JX, Liu BW, Ouyang YC, Guo JN, Dong MZ, Wang ZB^#, Gao F^#, Yao YQ^# (2022).Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice. Cell Prolif. Dec 8:e13372.
8. Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB^#, Sun QY^#, Liu J^# (2022).SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. Elife. Nov 10;11:e78211.
9. Meng TG, Lei WL, Lu X, Liu XY, Ma XS, Nie XQ, Zhao ZH, Li QN, Huang L, Hou Y, Ouyang YC, Li L, Tang TS, Schatten H, Xie W, Gao SR, Ou XH^#, Wang ZB^#, Sun QY^#（2022.Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis. Int J Biol Sci. Jul 11;18(11):4513-4531.
10. Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB^#, Sun QY^#（2022）. PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development. Development. May 15;149(10):dev200351.
11. Zhu FY, Wang LL, Meng TG, Wang RL, Yang ZX, Cao Y, Zhu GY, Jin Z, Gao LL , Zeng WT, Wang ZB^#, Sun QY^#, Zhang D^# (2021).Nature aging. 1(11):1-14.
12. Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y^#, Lin G^#, Wang Z^#, Xu W^#(2022). Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice. Hum Reprod. Feb 25:deac026.
13. Yue W, Wang Y, Meng TG, Zhang HY, Zhang XR, Ouyang YC, Hou Y, Schatten H, Wang ZB^#, Sun QY^#(2022). Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation. FASEB J.Mar;36(3):e22210
14. Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB^#, Qian WP^#, Sun QY^#(2021). Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis. Cell Death Dis.Sep 27;12(10):883.
15. Zhao BW, Sun SM, Xu K, Li YY, Lei WL, Li L, Liu SL, Ouyang YC, Sun QY^#, Wang ZB^#（2021）. FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes. Front Cell Dev Biol. Mar 25;9:647103. 
16. Meng TG*, Zhou Q*, Ma XS*, Liu XY*, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH^#, Wang ZB^#, Gao SR^#, Sun QY^#（2020）. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.Nat Commun. Dec 11;11(1):6354.
17. Zhao ZH, Meng TG, Li A, Schatten H, Wang ZB^#, Sun QY^#（2020）. RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization. BMC Genomics. Jul 10;21(1):475.
18. Zhou Q, Li J, Yue W, Li A, Meng TG, Lei WL, Fan LH, Ouyang YC, Schatten H, Wang ZB^#, Sun QY^# (2020). Cell division cycle 23 is required for mouse oocyte meiotic maturation. FASEB J. Jul;34(7):8990-9002. 
19. Zhou Q, Meng QR, Meng TG, He QL, Zhao ZH, Li QN, Lei WL, Liu SZ, Schatten H, Wang ZB^#, Sun QY^#（2020）. Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development. Mol Reprod Dev.May;87(5):550-564.
20. Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB^#, Sun QY^# (2019). Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. Jan;33(1):1179-1187
21. Lei R, Bai X, Chang Y, Li J, Qin Y, Chen K, Gu W, Xia S, Zhang J, Wang Z^#, Xing G^#（2018）.Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption. Int J Mol Sci. Mar 1;19(3).
22. Yuan Y, Ma XS, Liang QX, Xu ZY, Huang L, Meng TG, Lin F, Schatten H, Wang ZB^#, Sun QY^# (2017). Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility. J Reprod Dev. Oct 18;63(5):481-488.
23. Meng TG, Hu MW, Ma XS, Huang L, Liang QX, Yuan Y, Hou Y, Wang H, Schatten H, Wang ZB^#, Sun QY^# (2017). Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice. Cell Death Dis. Jun 1;8(6):e2846.
24. Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB^#, Sun QY^# (2016). Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. Dec 8;12(12):e1006513
25. Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB^#, Sun QY^# (2016). Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility. Mol Biol Cell. Mar 1;27(5):768-75.