本研究組的研究方向是以小鼠和果蠅等模式動物作為研究係統，利用分子生物學、細胞生物學、遺傳學和生物化學等技術在分子、細胞和個體（包括果蠅和小鼠）三個水平上進行探討：1）天然免疫反應的調控機製；2）免疫調控與癌症治療和自身免疫疾病的關係；3）幹細胞命運調控的分子機製。近年來所取得的研究成果發表在國際核心學術期刊，包括Nature Communications, Molecular Cell，PNAS，PLoS Pathogens, Stem Cell Reports, Immunity,和Blood等。

　　科技部國家重點研發計劃、中國科學院先導項目、國家自然科學基金項目等。

1. Zhang, G., Miao, Y., Song, Y., Wang, L., Li, Y., Zhu, Y., Zhang, W., Sun, Q.*, and Chen, D.* (2024) HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos. Proc Natl Acad Sci U S A 121, e2410261121
2. Li, Y., Zhao, D., Chen, D., and Sun, Q.* (2024) Targeting protein condensation in cGAS-STING signaling pathway. Bioessays 46, e2400091
3. Lin, Y., Yang, J., Yang, Q., Zeng, S., Zhang, J., Zhu, Y., Tong, Y., Li, L., Tan, W., Chen, D.*, and Sun, Q.* (2023) PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling. Nat Commun 14, 7567
4. Tao, X., Song, J., Song, Y., Zhang, Y., Yang, J., Zhang, P., Zhang, D., Chen, D.*, and Sun, Q.* (2022) Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase. Cell Rep 40, 111310
5. Gao, Y., Zhu, Y., Sun, Q.*, and Chen, D.* (2023) Argonaute-dependent ribosome-associated protein quality control. Trends Cell Biol 33, 260-272
6. Sun, J., Yang, Q., Liu, E., Chen, D.*, and Sun, Q.* (2022) KIZ/GM114 Balances the NF-kB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. Front Cell Dev Biol 10, 877039
7. Gu, H., Yang, J., Zhang, J., Song, Y., Zhang, Y., Xu, P., Zhu, Y., Wang, L., Zhang, P., Li, L., Chen, D.*, and Sun, Q.* (2022) PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nat Commun 13, 1564
8. Gao, Y., Zhu, Y., Wang, H., Cheng, Y., Zhao, D., Sun, Q.*, and Chen, D.* (2022) Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Mol Cell 82, 1313-1328 e1318（封麵文章）
9. Zhang, G., Xu, Y., Wang, X., Zhu, Y., Wang, L., Zhang, W., Wang, Y., Gao, Y., Wu, X., Cheng, Y., Sun, Q.*, and Chen, D.* (2022) Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nat Commun 13, 859
10. Tao, X., Chu, B., Xin, D., Li, L., and Sun, Q.* (2020) USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I. PLoS Pathog 16, e1008293
11. He, S., Zhang, G., Wang, J., Gao, Y., Sun, R., Cao, Z., Chen, Z., Zheng, X., Yuan, J., Luo, Y., Wang, X., Zhang, W., Zhang, P., Zhao, Y., He, C., Tao, Y.*, Sun, Q.*, and Chen, D.* (2019) 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nat Commun 10, 2219
12. Ji, S., Luo, Y., Cai, Q., Cao, Z., Zhao, Y., Mei, J., Li, C., Xia, P., Xie, Z., Xia, Z., Zhang, J., Sun, Q.*, and Chen, D.* (2019) LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan. Mol Cell 74, 363-377 e365
13. Ji, S., Li, C., Hu, L., Liu, K., Mei, J., Luo, Y., Tao, Y., Xia, Z., Sun, Q.*, and Chen, D.* (2017) Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Proc Natl Acad Sci U S A 114, 6316-6321
14. Lin, W., Zhang, J., Lin, H., Li, Z., Sun, X., Xin, D., Yang, M., Sun, L., Li, L., Wang, H., Chen, D., and Sun, Q.* (2016) Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun 7, 11848
15. Sun, X., Sun, L., Zhao, Y., Li, Y., Lin, W., Chen, D., and Sun, Q.* (2016) MAVS maintains mitochondrial homeostasis via autophagy. Cell Discov 2, 16024
16. Li, Z., Liu, G., Sun, L., Teng, Y., Guo, X., Jia, J., Sha, J., Yang, X., Chen, D., and Sun, Q.* (2015) PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation. PLoS Pathog 11, e1004783
17. Ji, S., Sun, M., Zheng, X., Li, L., Sun, L., Chen, D.*, and Sun, Q.* (2014) Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nat Commun 5, 3458
18. Zhao, Y., Sun, X., Nie, X., Sun, L., Tang, T. S., Chen, D., and Sun, Q.* (2012) COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production. PLoS Pathog 8, e1003086
19. Sun, Q., Sun, L., Liu, H. H., Chen, X., Seth, R. B., Forman, J., and Chen, Z. J.* (2006) The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24, 633-642
20. Sun, Q., Matta, H., and Chaudhary, P. M.* (2003) The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood 101, 1956-1961

　　歡迎對免疫和癌症免疫治療感興趣同學加盟我們的研究團隊。