周琪，博士，研究員，中國科學院院士，發展中國家科學院院士。現任中國科學院副院長、黨組成員，兼任中國科學院大學黨委書記、校長。曾任國家863計劃、973計劃、重大科學研究計劃、國家自然科學基金創新研究群體項目負責人，中國科學院幹細胞領域戰略性先導科技專項（A類）首席科學家。在動物克隆、幹細胞發育全能性及調控機製、新型幹細胞係創建、哺乳動物生殖新技術、細胞命運決定、幹細胞資源庫建立、幹細胞臨床應用研究等方麵取得多個係列原創性成果。研究成果多次入選國內、國際年度科技進展。獲得國家自然科學獎二等獎、中國科學院傑出科技成就獎、周光召基金會傑出青年基礎科學獎、何梁何利基金科學與技術進步獎、genOway國際轉基因技術獎、發展中國家科學院生物學獎等科技獎勵。

　　生殖、發育、幹細胞的基礎研究與轉化應用。

(注：^#為第一作者，*為通訊作者)

1. Wang LY^#, Li ZK^#, Wang LB^#, Liu C^#, Sun XH^#, Feng GH^#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell 2020 Aug 6;27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014. Epub 2020 Jun 18.
2. Fu R^#, Yu D^#, Ren J^#, Li C^#, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T*, Li W*, Zhou Q*. Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. Protein & Cell 2020 Feb;11(2):97-107. doi: 10.1007/s13238-019-00676-8. Epub 2019 Nov 28.
3. Cui T^#, Jiang L^#, Li T^#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W*, Zhou Q*. Derivation of Mouse Haploid Trophoblast Stem Cells. Cell Reports 2019 Jan 8;26(2):407-414.e5. doi: 10.1016/j.celrep.2018.12.067.
4. Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
5. Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell 2018 Nov 1;23(5):665-676.e4. doi: 10.1016/j.stem.2018.09.004. Epub 2018 Oct 11.
6. Wang YK^#, Zhu WW^#, Wu MH^#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q*, Hu BY*. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports 2018 Jul 10;11(1):171-182. doi: 10.1016/j.stemcr.2018.05.010. Epub 2018 Jun 14.
7. Li TD^#, Feng GH^#, Li YF^#, Wang M^#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q*. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):11974-11979. doi: 10.1073/pnas.1708710114. Epub 2017 Oct 23.
8. He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q*. Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening. Cell Reports 2017 Aug 29;20(9):2227-2237. doi: 10.1016/j.celrep.2017.07.081.
9. Gu Q^#, Wang J^#, Wang L^#, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports 2017 Jul 11;9(1):366-380. doi: 10.1016/j.stemcr.2017.04.017. Epub 2017 May 11.
10. Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 2016 Jan 14;164(1-2):279-292. doi: 10.1016/j.cell.2015.11.035.
11. Zhou Q^#, Wang M^#, Yuan Y^#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q*. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell 2016 Mar 3;18(3):330-340. doi: 10.1016/j.stem.2016.01.017. Epub 2016 Feb 25.
12. Chen Q^#*, Yan M^#, Cao Z^#, Li X^#, Zhang Y^#, Shi J^#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31.
13. Chen T^#, Hao YJ^#, Zhang Y^#, Li MM^#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. m⁶A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 2015 Mar 5;16(3):289-301. doi: 10.1016/j.stem.2015.01.016. Epub 2015 Feb 12.
14. Wan HF^#, Feng CJ^#, Teng F^#, Yang SH^#, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, Li W*, Zhao XY*, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Research 2015 Feb;25(2):258-261. doi: 10.1038/cr.2014.158. Epub 2014 Nov 28.
15. Li X^#, Wang JQ^#, Wang LY^#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. Journal of Molecular Cell Biology 2015 Oct;7(5):486-488. doi: 10.1093/jmcb/mjv055. Epub 2015 Aug 5.
16. Li W^#, Li X^#, Li TD^#, Jiang MG^#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 2014 Mar 6;14(3):404-414. doi: 10.1016/j.stem.2013.11.016. Epub 2013 Dec 19.
17. Hai T^#, Teng F^#, Guo RF, Li W, Zhou Q*. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Research 2014 Mar;24(3):372-375. doi: 10.1038/cr.2014.11. Epub 2014 Jan 31.
18. Zhou Q*. Balancing the welfare: the use of non-human primates in research. Trends in Genetics 2014 Nov;30(11):476-478. doi: 10.1016/j.tig.2014.09.005. Epub 2014 Oct 23.
19. Gu Q^#, Hao J^#, Hai T^#, Wang J^#, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein & Cell 2014 May;5(5):338-342. doi: 10.1007/s13238-014-0043-2.
20. Li W^#, Teng F^#, Li T, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnology 2013 Aug;31(8):684-686. doi: 10.1038/nbt.2652.
21. Wan HF^#, He ZQ^#, Dong MZ, Gu TT, Luo GZ, Teng F, Xia BL, Li W, Feng CJ, Li X, Li TD, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Research 2013 Nov;23(11):1330-1333. doi: 10.1038/cr.2013.126. Epub 2013 Sep 10.
22. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. Journal of Biological Chemistry 2013 Aug 16;288(33):23659-23665. doi: 10.1074/jbc.M113.475608. Epub 2013 Jul 2.
23. Li W^#, Shuai L^#, Wan H^#, Dong M^#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 2012 Oct 18;490(7420):407-411. doi: 10.1038/nature11435. Epub 2012 Sep 30.
24. Sheng C^#, Zheng Q^#, Wu J^#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*, Zhou Q*. Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Research 2012 Jan;22(1):208-218. doi: 10.1038/cr.2011.175. Epub 2011 Nov 8.
25. Tong M^#, Lv Z^#, Liu L^#, Zhu H^#, Zheng QY^#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH*, Zhou Q*. Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Research 2011 Nov;21(11):1634-1637. doi: 10.1038/cr.2011.143. Epub 2011 Aug 30.
26. Niu Y^#, Yu Y^#, Bernat A^#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji W*. Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 2010 Oct 12;107(41):17663-17667. doi: 10.1073/pnas.1006563107. Epub 2010 Sep 24.
27. Zhao XY, Lv Z, Li W, Zeng F*, Zhou Q*. Production of mice using iPS cells and tetraploid complementation. Nature Protocols 2010 May;5(5):963-971. doi: 10.1038/nprot.2010.61. Epub 2010 Apr 29.
28. Liu L^#, Luo GZ^#, Yang W^#, Zhao X^#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. Journal of Biological Chemistry 2010 Jun 18;285(25):19483-19490. doi: 10.1074/jbc.M110.131995. Epub 2010 Apr 9.
29. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. Nature 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.
30. Ma M^#, Guo X^#, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R*, Sha J, Zhou Q*. Protein expression profile of the mouse metaphase-II oocyte. Journal of Proteome Research 2008 Nov;7(11):4821-4830. doi: 10.1021/pr800392s. Epub 2008 Sep 20.
31. Mai Q^#, Yu Y^#, Li T, Wang L, Chen MJ, Huang SZ*, Zhou C*, Zhou Q*. Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Research 2007 Dec;17(12):1008-1019. doi: 10.1038/cr.2007.102.
32. Zhou Q^#*, Yang SH^#, Ding CH^#, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP*, Ji WZ*. A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Human Reproduction 2006 Oct;21(10):2564-2571. doi: 10.1093/humrep/del216. Epub 2006 Jun 22.
33. Li T, Zheng J, Xie Y, Wang S, Zhang X, Li J, Jin L, Ma Y, Wolf DP, Zhou Q*, Ji W*. Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells 2005 Oct;23(9):1295-1303. doi: 10.1634/stemcells.2005-0026. Epub 2005 Jul 28.
34. Zhou Q, Renard JP*, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. Generation of fertile cloned rats by regulating oocyte activation. Science 2003 Nov 14;302(5648):1179. doi: 10.1126/science.1088313. Epub 2003 Sep 25.
35. Zhou Q, Boulanger L, Renard JP*. A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. Cloning 2000;2(1):35-44. doi: 10.1089/15204550050145111.