伍一軍現任必威精装版app西汉姆联 研究員，博士研究生導師，主持分子毒理學實驗室，擔任研究組組長。中國科學院研究生院/必威在线网址 獲得理學博士學位後赴美國Medical College of Georgia分子醫學與遺傳學係完成博士後研究（基因調控方向）。先後赴University of Louisiana（1999-2000年）、Oregon Health & Science University（2007-2008年）、Duke University（2010-2011年）、Virginia Commonwealth University（2015-2016年）等高校作為高級研究學者從事學術訪問與合作研究。兼任中國科學院研究生院教授、中國科學技術大學博士生導師、必威精装版app西汉姆联 學位委員會委員、國家自然科學基金項目評審專家、教育部學位中心論文評審專家、中國毒理學會生化與分子毒理學專業委員會常務委員、中國毒理學會神經毒理學專業委員會副主任委員、中國環境誘變劑學會環境誘變劑及神經毒理專業委員會常務委員、國家食品藥品監督管理局化妝品安全專家委員會委員、北京市預防醫學會衛生毒理學專業委員會常務委員、中華醫學會《中華勞動衛生職業病雜誌》編委、《Scientific Reports》編委、《Insect Science》與《昆蟲學報》編委、《實驗動物學報》編委、《中國比較醫學雜誌》通訊編委、《農藥學學報》編委。

　　專業方向為分子毒理學/分子醫學，主要研究領域為神經毒理學、環境毒理學以及藥物引起的神經疾病。主要研究興趣是環境化學物的神經毒性機製；低劑量化學物的慢性毒性機理；化學物的聯合多毒性作用及其機製、有機磷引起的遲發性神經毒性的分子機製；神經病靶酯酶的功能與調節等。

　　先後主持承擔國家自然科學基金項目、中科院生物特別支持項目、國際合作項目、國家863計劃項目、國家973計劃項目（子課題），中國科學院知識創新工程重大項目（專題）、國家科技支撐計劃重大項目、中國科學院先導項目（子課題）等多項課題。近年來，帶領分子毒理學實驗室團隊運用現代生物學技術研究化學物的毒性效應機製以及食品安全中的汙染物毒性問題，取得重要進展。使用的模型包括細胞係、原代培養細胞、動物模型等，使用的技術手段和方法包括組學技術、細胞學技術、基因編輯技術、蛋白質相互作用技術、基因編輯技術等。已在國際重要核心學術期刊（SCI源刊）上發表研究論文近100篇。

　　已培養畢業博士生和碩士生27人，多人獲國家獎學金和中科院獎學金，畢業後赴美留學工作和從事博士後研究。國內就業單位中已有4位博士畢業生晉升為教授/研究員和博士生導師、8人晉升為副教授/副研究員和研究生導師。現有在讀博士生5人，碩士生3人。

1. Xu HY, Sun YJ, Sun YY, Wu YJ, Xu MY, Chen LP, Zhu L. Lapatinib alleviates TOCP-induced axonal damage in the spinal cord of mouse. Neuropharmacology. 2021, 189: 108535.
2. Li J, Qin Q, Li YX, Leng XF, Wu YJ. Tri-ortho-cresyl phosphate exposure leads to low egg production and poor eggshell quality via disrupting follicular development and shell gland function in laying hens. Ecotoxicol Environ Saf. 2021, 225: 112771.
3. Chen LP, Xing XJ, Kang KL, Yang WY, Luo L, Wu YJ. Why are Drosophila larvae more sensitive to avermectin than adults? Comp Biochem Physiol Part C. 2022, 251: 109197.
4. Wang P, Wu YJ, Sun ML. Decrease of an intracellular organic osmolyte contributes to the cytotoxicity of organophosphate in neuroblastoma cells in vitro. Toxicology. 2021, 453:152725.
5. Li Q, Li J, Kang KL, Wu YJ. A safety type of genetically engineered bacterium that degrades chemical pesticides. AMB Express. 2020, 10(1): e33.
6. Xu MY, Sun YJ, Wang P, Yang L, Wu YJ. Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos. Ecotoxicol Environ Saf. 2020, 195: 110467.
7. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Identification of metabolite biomarkers in serum of rats exposed to chlorpyrifos and cadmium. Sci Rep. 2020, 10(1): e4999.
8. Hou RY, Wang L, Wu YJ. Predicting ATP-binding cassette transporters using the random forest method. Front Genet. 2020, 11: 156.
9. Hou RY, Wu J, Xu L, Zou Q, Wu YJ. Computational prediction of protein arginine methylation based on composition-transition-distribution (CTD) features. ACS Omega. 2020, 5(42):27470-27479.
10. Wang P, Yang M, Jiang L, Wu YJ. A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway. Neuropharmacolgy. 2019, 148: 31-39.
11. Xu MY, Wang P, Sun YJ, Wu YJ. Disruption of kidney metabolism in rats after subchronic combined exposure to low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2019, 32 (1):122–129.
12. Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019, 38:265.
13. Liang YJ, Wang P, Wang HP, Long DX, Sun YJ, Wu YJ. Time-course changes in urine metabolic profiles of rats following 90-day exposure to propoxur. Sci Rep. 2019, 9(1): e16989.
14. Xu HY, Wang P, Sun YJ, Xu MY, Zhu L, Wu YJ. Activation of neuregulin 1/ErbB signaling is involved in the development of TOCP-induced delayed neuropathy. Front Mol Neurosci. 2018, 11:129.
15. Xu HY，Wang P, Sun YJ, Jiang L, Xu MY, Wu YJ. Autophagy in tri-o-cresyl phosphate-induced delayed neurotoxicity. J Neuropathol Exp Neurol. 2017, 76 (1): 52-60.
16. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells. Food Chem Toxicol. 2017, 103: 246-252.
17. Wang P, Wang J, Sun YJ, Yang L, Wu YJ. Cadmium and chlorpyrifos inhibit cellular immune response in spleen of rats. Environ Toxicol. 2017, 32: 1927-1936.
18. Xu MY, Wang P, Sun YJ, Wu YJ. Metabolomic analysis for combined hepatotoxicity of chlorpyrifos and cadmium in rats. Toxicology. 2017, 384: 50-58.
19. Wang P, Xu MY, Liang YJ, Wang HP, Sun YJ, Long DX, Wu YJ. Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. Chem-Biol Interact. 2017, 272: 21-27.
20. Long DX, Wang P, Sun YJ, Chen R, Wu YJ. Neuropathy target esterase is degraded by the ubiquitin-proteasome pathway with ARA54 as the ubiquitin ligase. Biochemistry. 2015, 54(50):7385-7392.
21. Wang P, Wang Q, Yang L, Qin QL, Wu YJ. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Life Sci. 2015, 131: 57-62.
22. Xu MY, Sun YJ, Wang P, Xu HY, Chen LP, Zhu L, Wu YJ. Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2015, 28 (6):1216-1223.
23. Wang P, Wu YJ. Applications of metabonomics to pesticide toxicology. Curr Drug Metab. 2015, 16(3): 191-199.
24. Wang P, Wang HP, Xu MY, Liang YJ, Sun YJ, Yang L, Li L, Li W, Wu YJ. Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study. Food Chem Toxicol 2014, 70:222-230.
25. Luo L, Sun YJ, Yang L, Huang S, Wu YJ. Abamectin induces P-glycoprotein expression in S2 cells via calcium/calmodulin/NF-κB pathway. Chem-Biol Interact. 2013, 203:430-439.
26. Chen JX, Sun YJ, Wang P, Long DX, Li W, Li L, Wu YJ. Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology. 2013, 310:92-97.
27. Luo L, Sun YJ, Wu YJ. Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways. Insect Biochem Mol Biol. 2013, 43:627-634.
28. Zhu L, Wang P, Qin QL, Zhang H, Wu YJ. Protective effect of polypeptide from larva of housefly (Musca domestica) on hydrogen peroxide-induced oxidative damage in HepG2 cells. Food Chem Toxicol. 2013, 60:385-390.
29. Sun YJ, Wang HP, Liang YJ, Yang L, Li W, Wu YJ. An NMR-based metabonomic investigation of the subacute effects of melamine in rats. J Proteome Res. 2012, 11: 2544-2550.
30. Liang YJ, Wang HP, Long DX, Wu YJ. Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats. Bioanalysis. 2012, 4(24):2897-2907
31. Wang Q, Wu YJ. Lysophosphatidylcholine induces Ca2+ mobilization in Jurkat human T lymphocytes and CTLL-2 mouse T lymphocytes by different pathways. Eur J Pharm Sci. 2011, 44: 602-609.
32. Chen JX, Long DX, Hou WY, Li W, Wu YJ. Regulation of neuropathy target esterase by the cAMP/protein kinase A signal. Pharmacol Res. 2010,62: 259-264.
33. Chang PA, Wu YJ. Neuropathy target esterase: An essential enzyme for neural development and axonal maintenance, Int J Biocehm Cell Biol. 2010, 42:573-575.
34. Long DX, Chang PA, Liang YJ, Yang L, Wu YJ. Degradation of neuropathy target esterase by macroautophagic lysosomal pathway. Life Sci. 2009, 84:89-96.
35. Li Q, Wu YJ. A fluorescent, genetically engineered micro-organism that degrades organophosphates and commits suicide when required. Appl Microbiol Biotechnol. 2009, 82:749-756.
36. Liu CY, Chang PA, Wu YJ. Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? Chem-Biol Interact. 2009, 181:37-44.
37. Hou WY, Long DX, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate. Toxicol Sci. 2009, 109:276-285.
38. Long DX, Wu YJ. Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate. Toxicol Lett. 2008, 181:47-52.
39. Hou WY, Long DX, Wang HP, Wang Q, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate induced delayed neurotoxicity in hens. Toxicology. 2008, 252:56-63.
40. Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80:886-892.
41. Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.
42. Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environ Toxicol Pharmacol. 2007, 24:67-71.
43. Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2007, 424:22-26.
44. Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159: 65-72.
45. Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39: 429-440.