李向東，男，博士，研究員，博士生導師；現為必威精装版app西汉姆联 細胞運動與肌肉收縮研究組組長，兼任農業蟲害鼠害綜合治理研究國家重點實驗室副主任。1990年華東化工學院生物化學專業學士畢業，1993年中國科學院上海昆蟲研究所碩士畢業，1996年中國科學院上海生物化學研究所博士畢業，1996-2009年在美國馬薩諸塞大學醫學院從事研究工作，先後擔任博士後，講師和研究助理教授。2009年擔任必威精装版app西汉姆联 研究員，主要從事細胞內物質轉運的分子機製研究及無脊椎動物肌肉係統發育調節研究。近年來取得的研究成果主要發表於國際核心學術期刊，包括PNAS, J. Biol. Chem., Biochemistry, Insect Molecular Biology等。

• American Heart Association Postdoctoral Fellowship (1999–2001)

• 國家自然科學基金麵上項目（31672359）可變剪切部位調節飛蝗橫紋肌肌球蛋白馬達功能的分子機製（2017.01-2020.12），項目負責人
• 國家自然科學基金麵上項目（31470791）平滑肌肌球蛋白磷酸化調節的分子機理（2015.01-2018.12），項目負責人
• 國家重大科學研究計劃973項目納米生物機器的可控組裝與多功能集成/課題二（2013CB932802）蛋白質納米機器係統的功能集成研究（2013.01-2017.12），課題負責人
• 國家重點基礎研究發展規劃973項目害蟲暴發成災的遺傳與行為機理/課題二（2012CB114102）害蟲種群暴發的行為遺傳機製（2012.01-2016.12），課題骨幹
• 國家自然科學基金麵上項目（31171367）非典型肌球蛋白V 調節機理的研究（2012.01-2015.12），項目負責人
• 國家自然科學基金麵上項目（31071973）昆蟲特有肌球蛋白的功能與調節研究（2011.01-2013.12），項目負責人
• 中國科學院知識創新工程前沿領域項目（KSCX2-YW-N-072）昆蟲肌肉收縮機理研究（2009.01-2011.12），項目負責人
• American Heart Association - Scientist Development Grant (0530211N), Regulation of myosin-Va (2004.1-2008.12)，項目負責人

（*通訊作者, #共同第一作者）

1. Hui-Fang Liang and Xiang-dong Li* (2022) Locusta migratoria flight muscle troponin partially activates thin filament in a calcium-dependent manner. Insect Molecular Biology 31:346–355. 
2. Ning Zhang#, Shu-Jie Zhou#, Huan-Hong Ji, and Xiang-dong Li* (2022) Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin. Cell Calcium 103: 102549.
3. Tong Ni#, Min Yuan#, Huan-Hong Ji, Guangfei Tang, Yun Chen, Zhonghua Ma, and Xiang-dong Li* (2020) Effects of Mutations in the Phenamacril-Binding Site of Fusarium Myosin-1 on Its Motor Function and Phenamacril Sensitivity. ACS Omega 5: 21815-21823.
4. Hui-Fang Liang, Jing Li, and Xiang-dong Li* (2020) Identification and characterization of troponin genes in Locusta migratoria. Insect Molecular Biology 29(4): 391-403.
5. Qing-Juan Cao^#, Ning Zhang^#, Rui Zhou, Lin-Lin Yao, and Xiang-dong Li* (2019) The cargo adaptor proteins RILPL2 and melanophilin co-regulate myosin-5a motor activity. Journal of Biological Chemistry 294 (29): 11333–11341.
6. Huan-Hong Ji^#, Lin-Lin Yao^#, Chang Liu, and Xiang-dong Li* (2019) Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2. Bioscience Reports 39 (1): BSR20181252.
7. Ning Zhang^#, Lin-Lin Yao^#, and Xiang-dong Li* (2018) Regulation of Class V Myosin. Cellular and Molecular Life Science 75(2): 261-273.
8. Hai-Man Zhang, Huan-Hong Ji, Tong Ni, Rong-Na Ma, Aibing Wang, and Xiang-dong Li* (2017) Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2. Biochemistry 56(32):4235-4243.
9. Ning Zhang and Xiang-dong Li* (2017) Directional Transportation of Assembled Molecular Linear Motors, in Supramolecular Chemistry of Biomimetic Systems (Li, J., Ed.) Springer Nature, Singapore.
10. Mei Shen^#, Ning Zhang^#, Sanduo Zheng^#, Wen-Bo Zhang, Hai-Man Zhang, Zekuan Lu, Qian Peter Su, Yujie Sun, Keqiong Ye, and Xiang-dong Li* (2016) Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor. Proceedings of the National Academy of Sciences USA 113: E5812-E5820.
11. Jing Li, Zekuan Lu, Jing He, Qianquan Chen, Xianhui Wang, Le Kang, and Xiang-dong Li* (2016) Alternative Exon-encoding Regions of Locusta migratoria Muscle Myosin Modulate the pH dependence of ATPase Activity. Insect Molecular Biology 25:689-700.
12. Nan Chen, Yong-Liang Fan*, Yu Bai, Xiang-dong Li, Zhan-Feng Zhang, and Tong-Xian Liu* (2016) Cytochrome P450 gene, CYP4G15, modulates hydrocarbon production in the pea aphid, Acyrthosiphon pisum. Insect Biochemistry and Molecular Biology 76: 84-94.
13. Lin-Lin Yao, Mei Shen, Zekuan Lu, Mitsuo Ikebe, and Xiang-dong Li* (2016a) Identification of the isoform-specific interactions between the tail and the head of class V myosin. Journal of Biological Chemistry 291: 8241-8250.
14. Wen-Bo Zhang, Lin-Lin Yao, and Xiang-dong Li* (2016b) The Globular Tail Domain of Myosin-5a Functions As a Dimer in Regulating the Motor Activity Journal of Biological Chemistry 291: 13571 -13579.
15. Hanna Witwick, Hong Jia, Artem Kutikov, Pablo Reyes-Gutierrez, Xiang-dong Li, Paul R. Odgren* (2015) TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption. PLOS ONE 10: e0127537
16. Chengqi Zhang^#, Yun Chen^#, Yanni Yin, Huan-Hong Ji, Won-Bo Shim, Yiping Hou, Mingguo Zhou*, Xiang-dong Li*, and Zhonghua Ma* (2015) A small molecule species-specifically inhibits Fusarium myosin I. Environmental Microbiology 17(8): 2735–2746.
17. Huan-Hong Ji, Hai-Man Zhang, Mei Shen, Lin-Lin Yao, Xiang-dong Li* (2015) The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11. Biochemical Journal 469 (1):135-144.
18. Lin-Lin Yao^#, Qing-Juan Cao^#, Hai-Man Zhang^#, Jie Zhang, Yang Cao, and Xiang-dong Li* (2015) Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5a. Scientific Reports 5:10874.
19. Zekuan Lu, Xiao-Nan Ma, Hai-Man Zhang, Huan-Hong Ji, Hao Ding, Jie Zhang, Dan Luo, Yujie Sun, and Xiang-dong Li* (2014) Mouse Myosin-19 is a Plus-end-directed, High-duty Ratio Molecular Motor. Journal of Biological Chemistry 289: 18535–18548.
20. Yang Cao, Howard D. White, and Xiang-dong Li* (2014) Drosophila myosin-xx functions as an actin-binding protein to facilitate the interaction between zyx102 and actin. Biochemistry 53, 350–360.
21. Rong-Na Ma, Katsuhide Mabuchi, Jing Li, Zekuan Lu, Chih-Lueh Albert Wang, and Xiang-dong Li* (2013) Cooperation between the Two Heads of Smooth Muscle Myosin Is Essential for Full Activation of the Motor Function by Phosphorylation. Biochemistry 52, 6240-6248.
22. Zekuan Lu^#, Mei Shen^#, Yang Cao, Hai-Man Zhang, Lin-Lin Yao, Xiang-dong Li* (2012) Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a. Journal of Biological Chemistry 287: 16530-16540.
23. 曹洋,沈梅，張潔，李向東* (2011) 果蠅非常規肌球蛋白的結構與功能.應用昆蟲學報 48: 239-246.
24. Nobuhisa Umeki, Hyun Suk Jung, Shinya Watanabe, Tsuyoshi Sakai, Xiang-dong Li, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe* (2009）The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA Proceedings of the National Academy of Sciences USA 106:8483-8.
25. Xiang-dong Li*, Hyun Suk Jung, Qizhi Wang, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe (2008) The globular tail domain puts on the brake to stop the ATPase cycle of the myosin Va. Proceedings of the National Academy of Sciences USA 105: 1140-1145 (Citied in “Faculty of 1000”).
26. Zhiping Wang, Jeffrey G. Edwards, Nathan Riley, D. William Provance, Jr., Ryan Karcher, Xiang-dong Li, Ian G. Davison, Mitsuo Ikebe, John A. Mercer, Julie A. Kauer, and Michael D. Ehlers* (2008) Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell 135, 535-548.
27. Osamu Sato, Xiang-dong Li, and Mitsuo Ikebe* (2007) Myosin Va becomes a low duty ratio motor in the inhibited form. Journal of Biological Chemistry 282:13228-13239.
28. Xiang-dong Li^*, Hyun Suk Jung, Katsuhide Mabuchi, Roger Craig, and Mitsuo Ikebe (2006) The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor. Journal of Biological Chemistry 281:21789-21798 (Citied in “Faculty of 1000”).
29. Xiang-dong Li, Reiko Ikebe, and Mitsuo Ikebe* (2005) Activation of Myosin Va function by melanophilin, a specific docking partner of Myosin Va. Journal of Biological Chemistry 278: 29435-29441.
30. Xiang-dong Li, Katsuhide Mabuchi, Reiko Ikebe, and Mitsuo Ikebe* (2004) Ca²⁺ induced activation of ATPase activity of myosin Va is accompanied with a large conformational change. Biochemical and Biophysical Research Communications 315: 538-545.
31. Xiang-dong Li and Mitsuo Ikebe* (2003) Two functional heads are required for full activation of smooth muscle myosin. Journal of Biological Chemistry 278: 29435-29441.
32. Yu Chen, Norio Takizawa, Jessica L Crowley, Sang W. Oh, Cheryl L. Gatto, Taketoshi Kambara, Osamu Sato, Xiang-dong Li, Mitsuo Ikebe, and Elizabeth J. Luna* (2003) F-actin and myosin II binding domains in supervillin. Journal of Biological Chemistry  278:46094-46106
33. Xin Zhou, Xiang-dong Li, Jian-zhong Yuan, Zhen-hua Tang, and Wang-yi Li* (2000) Toxicity of Cinnamomin-A new type II ribosome-inactivating protein to ballworm and mosquito. Insect Biochemistry and Molecular Biology 30(3): 259-264
34. Xiang-dong Li, Junya Saito, Reiko Ikebe, Katsuhide Mabuchi, and Mitsuo Ikebe* (2000) The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin. Biochemistry 39(9): 2254-2260.
35. Xiang-dong Li, Troy E. Rhodes, Reiko Ikebe, Taketoshi Kambara, Howard D. White and Mitsuo Ikebe* (1998) Effects of mutations in the g-phosphate binding site of myosin on its motor function. Journal of Biological Chemistry 273(42): 27404-27411.
36. Wang-yi Liu*, Huai-yang Chen, Wen-feng Chen, Xiang-dong Li, Norbert Ulbrich and Werner Schroder (1997) A proposed position of a disulfide bridge in the molecules of cinnamomin and porrectin-two new type II ribosome-inactivating proteins isolated from the seeds of camphor trees. Biochemistry and Molecular Biology International 44(5): 1045-1049.
37. Xiang-dong Li, Wen-feng Chen, Wang-yi Liu*, and Gui-hai Wang (1997) Large-scale purification of two new ribosome-inactivating proteins --- cinnamomin and camphorin from the seed of Cinnamomum camphora. Protein Expression and Purification 10:27-31.
38. 李向東，劉望夷* (1997) 核糖體失活蛋白研究進展。生命的化學17(2): 15-18.
39. 李向東,劉望夷* (1997) 核糖體失活蛋白結構功能與分布。細胞生物學雜誌19(2): 69-75.
40. Xiang-dong Li, Wang-yi Liu*, and Ching-i Niu. (1996)  Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein. Biological Chemistry, 377: 825-831.
41. Jun Ling, Xiang-dong Li, Xiao-hua Wu, and Wang-yi Liu* (1995) Topological requirements for recognition and cleavage of DNA by ribosome-inactivating proteins. Biological Chemistry Hoppe-Seyler, 376: 637-641.
42. 李向東， 唐振華* (1993) 馬拉硫磷羧酸酯酶在小菜蛾抗藥性中的作用. 昆蟲學研究集刊11: 1-10.