韓春生，博士，研究員，博士生導師；必威精装版app西汉姆联 精原幹細胞研究組組長。科技部戰略性國際科技創新合作重點專項負責人。長期在中國科學院研究生院主講“實用生物信息學”課程，多次獲得優秀課程獎，並獲得“中國科學院朱李月華優秀教師獎”。

1990年複旦大學生物工程係遺傳工程專業本科畢業；1993年獲生殖生物學國家重點實驗室生理學碩士；2000年獲美國密蘇裏大學生物化學係博士學位；2000年至2003年任美國Lexicon Genetics & Pharmaceuticals 公司高級生物信息科學家。歸國前曾從事胚胎植入、幹擾素信號通路、藥物研發等領域的研究。目前主要從事不育治療新技術的研發，包括兩個方向：1. 生殖細胞形成、發育、減數分裂；2. 精原幹細胞增殖、分化、重編程。曾承擔國家自然科學基金、科技部重大研究計劃、“973”等項目的研究課題。作為第一或通訊作者在 Science Advances、Nature Communications、Nucleic Acid Research、Cell Research、EMBO reports, Molecular and Cellular Proteomics、Development、RNA、Stem Cell Reports等期刊發表SCI論文70餘篇。已培養博士畢業生24人、碩士生11人、博士後4人。目前在讀博士生8人、碩士生4人。

1. 科技創新2030-農業生物育種重大項目子課題“幹細胞建係及向配子誘導分化”，2023/12 ~ 2025/12;
2. 科技部重點研發計劃：“計劃生命孕育關鍵環節的分子機製研究“，2019/08 ~ 2023/07;
3. 科技部重點計劃子課題：“多能幹細胞向生殖細胞分化模型及調控機製”，2012/01 ~ 2016/12；
4. 科技部重大計劃子課題：“原始生殖細胞特化和定向遷移”，2013/01 ~ 2017/12；
5. 自然科學基金麵上項目：

---“RBFOX2調控減數分裂啟動的機製研究”，2024/01-2027/12；

---“BEND2在小鼠生精細胞減數分裂中的分子機製”，2020/01-2023/12；

---“利用miRNAs誘導小鼠iPS細胞形成精原幹細胞樣細胞”，2018/01-2021/12；

---“轉錄因子RFX2調控小鼠精子細胞發育基因轉錄及表觀遺傳狀態的機理”，2015/01-2018/12；

---“小鼠中來源於mRNA的piRNA的生成機理研究”，2013/01 ~ 2016/12；

1. Wang X, Wang Y, Wang Y, Guo Y, Zong R, Hu S, Yue J, Yao J, Han C*, Guo J*, Zhao J*. Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty. Commun Biol. 2024 Nov 9;7(1):1478. doi: 10.1038/s42003-024-07163-9.
2. Han C*. Gene expression programs in mammalian spermatogenesis. Development. 2024 Apr 15;151(8):dev202033. doi: 10.1242/dev.202033.
3. Ning Y, Duo S, Lin X, Zhang H, Fei J, Zhang B, Zeng Y, Xie D, Chen J, Liu X, Han C*. Transcription factor PBX4 regulates limb development and haematopoiesis in mice. Cell Prolif. 2024 Jan 17:e13580. doi: 10.1111/cpr.13580. Epub ahead of print. PMID: 38230761.
4. Li J, Lin X, Xie L, Zhao J, Han C*, Deng H*, Xu J*，A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency，Life Medicine, 2023, lnad037, https://doi.org/10.1093/lifemedi/lnad037
5. Yan L, Chen J, Ning Y, Hac C*. Loss of RBFOX2 inhibits meiotic initiation in male mice[J]. Chinese Journal of Biotechnology, 2023, 39(10): 4108-4122
6. Lu C, Qin C, Fu Z, Wang L, Yi Y, Xin M, Zhen X, Han C*, Lu C*. Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses. Clin Transl Med. 2022 Oct;12(10):e1006.
7. Ma, L., Xie, D., Luo, M., Lin, X., Nie, H., Chen, J., Gao, C., Duo, S., and Han, C. (2022) Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis. Science Advances, 8(21):eabn1606.
8. Chen, J., Gao, C., Luo, M., Zheng, C., Lin, X., Ning, Y., Ma, L., He, W., Xie, D., Liu, K., Hong, K., Han, C. (2022) MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage. EMBO Reports, 17;e54298.
9. Chen, J., Gao, C., Lin, X., Ning, Y., He, W., Zheng, C., Zhang, D., Yan, L., Jiang, B., Zhao, Y., Hossen, MA., Han, C. (2021) The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis. Development, 148(24)
10. Zheng, C., Ouyang, YC., Jiang, B., Lin, X., Chen, J., Dong, MZ., Zhuang, X., Yuan, S., Sun, QY., Han C. (2019) Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice. Biology of Reproduction, 100(6)
11. Zhang, D., Xie, D., Lin, X., Ma, L., Chen, J., Wang, Y., Duo, S., Feng, Y., Zheng, C., Jiang, B., Ning, Y., Han, C.(2018) The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Development,145. doi: 10.1242/dev.164723.
12. Feng, Y., Ning, Y., Lin, X., Zhang, D., Liao, S., Zheng, C., Chen J., Wang Y., Ma L., Xie D., Han C.(2018) Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog. Stem Cells Dev, 27:692-703.
13. Hu, X., Shen, B., Liao, S., Ning, Y., Ma, L., Chen, J., Lin, X., Zhang, D., Li, Z., Zheng, C., Feng, Y., Huang, X., Han C.(2017) Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. Cell Death Di, 8:e2910.
14. Chen, J., Cai, T., Zheng, C., Lin, X., Wang, G., Liao, S., Wang, X., Gan, H., Zhang, D., Hu, X., Wang, S., Li, Z., Feng, Y., Yang, F., and Han, C. (2017) MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, Nucleic Acids Res. 45(7):4142-4157.
15. Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. A., and Liu, K. (2017) Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Proc Natl Acad Sci U S A, 114:592-597.
16. Chen, M., Zhang, L., Cui, X., Lin, X., Li, Y., Wang, Y., Wang, Y., Qin, Y., Chen, D., Han, C., Zhou, B., Huff, V., and Gao, F. (2017) Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Development 144, 44-53.
17. Wang, S., Wang, X., Ma, L., Lin, X., Zhang, D., Li, Z., Wu, Y., Zheng, C., Feng, X., Liao, S., Feng, Y., Chen, J., Hu, X., Wang, M., and Han, C. (2016) Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Stem cell reports 7, 80-94.
18. Lin, X., Han, M., Cheng, L., Chen, J., Zhang, Z., Shen, T., Wang, M., Wen, B., Ni, T., and Han, C. (2016) Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, RNA biology 13, 1011-1024.
19. Wu, Y., Hu, X., Li, Z., Wang, M., Li, S., Wang, X., Lin, X., Liao, S., Zhang, Z., Feng, X., Wang, S., Cui, X., Wang, Y., Gao, F., Hess, R. A., and Han, C. (2016) Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Scientific reports 6, 20435.
20. Yang, Y., Feng, Y., Feng, X., Liao, S., Wang, X., Gan, H., Wang, L., Lin, X., and Han, C. (2016) BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Stem cells international 2016, 9536192.
21. Xue, Y., Lameijer, E. W., Ye, K., Zhang, K., Chang, S., Wang, X., Wu, J., Gao, G., Zhao, F., Li, J., Han, C., Xu, S., Xiao, J., Yang, X., Ying, X., Zhang, X., Chen, W. H., Liu, Y., Zhang, Z., Huang, K., and Yu, J. (2016) Precision Medicine: What Challenges Are We Facing?, Genomics, proteomics & bioinformatics 14, 253-261.
22. Gao, Y., Bai, X., Zhang, D., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., Gao, F., and Qin, Y. (2016) Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis, Nature structural & molecular biology 23, 441-449.
23. #Zhu, L., #Han, C. S., Cao, Z. L., Wang, Z. B., Han, R. G., Wang, B., and Sun, Q. Y. (2015) Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, Gynecologic and obstetric investigation 80, 179-186.
24. Wang S.，Wang Xx.，Wu Yj.， and *Han, C. (2015) , IGF-1R Signaling Is Essential for the Proliferation of Cultured Mouse Spermatogonial Stem Cells by Promoting the G2/M Progression of the Cell Cycle，Stem Cells and Development 24,471-483
25. *Han, C. (2014) , Which one is the real matchmaker for the pair?，Asian Journal of Andrology 16,667-668.
26. Li, Y., Wang, X., Feng, X., Liao, S., Zhang, D., Cui, X., Gao, F., and *Han, C. (2014) Generation of male germ cells from mouse induced pluripotent stem cells in vitro, Stem Cell Res 12, 517-530.
27. Gan, H., Wen, L., Liao, S., Lin, X., Ma, T., Liu, J., Song, C.-x., Wang, M., He, C., *Han, C., and *Tang, F. (2013) Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis，Nature Communications 4, 1995.
28. Wang, F., Yang, Y., Lin, X., Wang, J. Q., Wu, Y. S., Xie, W., Wang, D., Zhu, S., Liao, Y. Q., Sun, Q., Yang, Y. G., *Guo, C., *Han, C., and *Tang, T. S. (2013) Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington's Disease, Human Molecular Genetics 22, 3641-3653.
29. Wu, Y., Liao, S., Wang, X., Wang, S., Wang, M., and Han, C.* (2013) HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm, FEBS Letters (10.1016/j.febslet.2013.04.049).
30. Shi, Y., Zhuang, X., Xu, B., Hua, J., Liao, S., Shi, Q., Cooke, H. J., Han, C.* (2013) SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60, Gene（10.1016/j.gene.2013.06.033）
31. Gan, H., Cai, T., Lin, X., Wu, Y., Wang, X., Yang, F., and Han, C.* (2013) Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis, Mol Cell Proteomics 12, 1144-1157.
32. Hou, X., Zhang, W., Xiao, Z., Gan, H., Lin, X., Liao, S., and Han, C.* (2012) Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis, BMC Genomics 13, 495.
33. Zhang, Y., Wang, S., Wang, X., Liao, S., Wu, Y., and Han, C.* (2012) Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells, Cell Research 22, 773-776.
34. Gan, H., Lin, X., Zhang, Z., Zhang, W., Liao, S., Wang, L., and Han, C.* (2011) piRNA profiling during specific stages of mouse spermatogenesis, RNA 17, 1191-1203.
35. Zhuang, X. J., Hou, X. J., Liao, S. Y., Wang, X. X., Cooke, H. J., Zhang, M., and Han, C.* (2011) SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice, PLoS One 6, e20866.
36. Shi, Y. Q., Liao, S. Y., Zhuang, X. J., and Han, C. S.* (2011) Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37, Gene 485, 153-159.
37. Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas, The Journal of biological chemistry 286, 28520-28532.
38. Liu, H., Wang, B., and Han, C.* (2011) Meta-analysis of genome-wide and replication association studies on prostate cancer, The Prostate 71, 209-224.
39. Yang, Y., and Han, C.* (2010) GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway, BMC cell biology 11, 78.
40. Shi, Y. Q., Li, Y. C., Hu, X. Q., Liu, T., Liao, S. Y., Guo, J., Huang, L., Hu, Z. Y., Tang, A. Y., Lee, K. F., Yeung, W. S., Han, C. S.*, and Liu, Y. X. (2009) Male germ cell-specific protein Trs4 binds to multiple proteins, BBRC 388, 583-588.
41. Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C., and Han, C.* (2008) Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase, Cell research 18, 800-802.
42. Zhang, K., Shang, Y., Liao, S., Zhang, W., Nian, H., Liu, Y., Chen, Q., and Han, C.* (2007) Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis, BBRC 360, 327-332.
43. Nian, H., Fan, C., Liao, S., Shi, Y., Zhang, K., Liu, Y., and Han, C.* (2007) RNF151, a testis-specific RING finger protein, interacts with dysbindin, Archives of biochemistry and biophysics 465, 157-163.
44. Shi, Y. Q., Wang, Q. Z., Liao, S. Y., Zhang, Y., Liu, Y. X., and Han, C. S.* (2006) In vitro propagation of spermatogonial stem cells from KM mice, Front Biosci 11, 2614-2622.
45. Walke, D. W., Han, C., Shaw, J., Wann, E., Zambrowicz, B., and Sands, A. (2001) In vivo drug target discovery: identifying the best targets from the genome, Current opinion in biotechnology 12, 626-631.
46. Han, C. S.*, Chen, Y., Ezashi, T., and Roberts, R. M. (2001) Antiviral activities of the soluble extracellular domains of type I interferon receptors, PNAS 98, 6138-6143.

　　“Never discourage anyone who continually makes progress, no matter how slow.”---Plato (427-327 BC)